Adiponectin and the development of type 2 diabetes - The atherosclerosis risk in communities study
Adiponectin and the development of type 2 diabetes - The atherosclerosis risk in communities study
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DOI：
10.2337/diabetes.53.9.2473
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发表时间：
2004-09-01
期刊：
影响因子：
7.7
通讯作者：
Heiss, G
中科院分区：
文献类型：
--
作者：
Duncan, BB;Schmidt, MI;Heiss, G
脂肪细胞源性分泌蛋白与糖尿病的关系日益密切。为了研究脂联素（一种主要的脂肪细胞分泌蛋白）是否能预测糖尿病，我们进行了一项病例队列研究，该研究代表了10，275名中年、非裔美国人和白色人参与社区动脉粥样硬化风险（ARIC）研究的9年经验。测定了581例糖尿病患者和572例非糖尿病患者的血浆脂联素水平。对于第二、第三和第四阶段的患者，发生糖尿病的总体风险比（95% CI）脂联素的四分位数为0.57（0.41-0.78）、0.39（0.27-0.56）和0.18校正年龄、性别、种族、研究中心、父母糖尿病史和高血压后，分别为（0.11-0.27）和0.72（0.48-1.09）、0.67（0.43-1.04）和0.58（0.34-0.99），在额外调整BMI、腰臀比、空腹血糖、胰岛素和由六种炎症标志物组成的评分后。这种关联在男性、女性、白人和非裔美国人中的程度相似，但在吸烟者和炎症评分较高的人群中不存在（相互作用P
Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the similar to9-year experience of the 10,275 middle-aged, U.S. African-American and white participants of the Atherosclerosis Risk in Communities (ARIC) study. Adiponectin was measured on stored plasma of 581 incident diabetes case subjects and 572 noncase subjects. Overall hazard ratios (95% CIs) for developing diabetes, for those in the second, third, and fourth (versus the first) quartile of adiponectin were 0.57 (0.41-0.78), 0.39 (0.27-0.56), and 0.18 (0.11-0.27), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, and hypertension and 0.72 (0.48-1.09), 0.67 (0.43-1.04), and 0.58 (0.34-0.99), respectively, after additional adjustment for BMI, waist-to-hip ratio, fasting glucose, insulin, and a score composed of six inflammation markers. The association was of similar magnitude in men and women and in whites and African Americans, but was absent in smokers and in those with a greater inflammation score (interaction P