PLASMODIUM-BERGHEI - IMMUNIZATION OF MICE AGAINST ANKA STRAIN USING UNALTERED SPOROZOITE AS AN ANTIGEN
PLASMODIUM-BERGHEI - IMMUNIZATION OF MICE AGAINST ANKA STRAIN USING UNALTERED SPOROZOITE AS AN ANTIGEN
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DOI：
10.1016/0014-4894(77)90054-6
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发表时间：
1977-01-01
影响因子：
2.1
通讯作者：
TUBERGEN, TA
中科院分区：
文献类型：
--
作者：
BEAUDOIN, RL;STROME, CPA;TUBERGEN, TA
用伯氏疟原虫的正常子孢子对小鼠进行免疫。测试小鼠在整个免疫期间接受抑制剂量的氯喹，并在攻击前接受治疗性伯氨喹疗程。所有小鼠都在子孢子攻击中幸存下来，但在感染红细胞的攻击中屈服。正常的感染性子孢子显然具有免疫原性，并且会刺激一定程度的针对子孢子攻击的保护，与用X射线照射的子孢子免疫所获得的保护程度相当。描述了从蚊子组织中分离子孢子的双相密度梯度。
Mice were immunized with normal sporozoites of P. berghei. Test mice were placed on suppressive doses of chloroquine throughout the immunization period and were given curative courses of primaquine prior to challenge. All mice survived sporozoite challenge but succumbed to challenge with infected erythrocytes. The normal infective sporozoite is apparently immunogenic and will stimulate a degree of protection against sporozoite challenge comparable to that obtained by immunization with X-ray irradiated sporozoites. A biphasic density gradient for separating sporozoites from mosquito tissue is described.