Misonidazole enhancement of the action of BCNU and melphalan against human melanoma xenografts.
Misonidazole enhancement of the action of BCNU and melphalan against human melanoma xenografts.
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米索硝唑增强 BCNU 和美法仑对人黑色素瘤异种移植物的作用。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
T. Mcelwain
中科院分区：
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作者：
R. Clutterbuck;J. Millar;T. Mcelwain
我们研究了BCNU和咪唑硝唑、马法兰和咪唑硝唑联合应用对免疫剥夺小鼠体内两株人恶性黑色素瘤移植瘤生长延迟的影响。咪唑本身对这些肿瘤的生长没有影响，但BCNU-咪唑和马法兰-咪唑的联合应用比单独使用细胞毒药物产生的肿瘤生长延迟更大。伴随而来的是体重减轻的增加。咪唑与马法兰联合使用也会增加造血干细胞的毒性，但在BCNU的情况下，在为肿瘤实验选择的剂量下，没有增强骨髓毒性。
We investigated the effects of combinations of BCNU and misonidazole, and melphalan and misonidazole on growth delay in two human malignant melanoma xenograft lines grown in immune-deprived mice. Misonidazole on its own had no effect on the growth of these tumors, but combinations of BCNU-misonidazole and melphalan-misonidazole produced greater tumor growth delays than those produced by the cytotoxic drugs alone. This was accompanied by increased weight loss. Misonidazole in combination with melphalan also increases hemopoietic stem cell toxicity, but in the case of BCNU there was no enhancement of bone marrow toxicity at the dose chosen for tumor experiments.