Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine
Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine
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DOI：
10.1016/j.jpsychires.2006.07.006
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发表时间：
2007-11-01
影响因子：
4.8
通讯作者：
Ogur, Erkin
中科院分区：
文献类型：
--
作者：
Atmaca, Murad;Ozdemir, Huseyin;Ogur, Erkin
在双相情感障碍患者中，最近的脑成像研究报告了扣带皮层体积的变化。我们进行了体积磁共振成像 (MRI) 研究来评估扣带回的子区域；左前扣带回 (LAC)、左后扣带回 (LPC)、右前扣带回 (RAC) 和右后扣带回 (RPC)。我们的样本由未接受药物治疗 (n = 10)、丙戊酸钠单药治疗 (n = 10) 或丙戊酸加喹硫平 (n = 10) 与健康对照 (n = 10) 的双相情感障碍患者组成。招募了 30 名右利双相情感障碍患者。其中，10 例为首次用药且从未服用过任何药物的患者（初治组），10 例接受丙戊酸治疗（丙戊酸组），10 例接受丙戊酸加喹硫平治疗（丙戊酸加喹硫平组）。扣带回体积包括皮质和白质。与丙戊酸组和丙戊酸加喹硫平组以及健康对照相比，未用药患者的 LAC 和 LPC 体积显着较小。此外，在事后比较中，丙戊酸加喹硫平组与丙戊酸单独组之间发现了显着差异的趋势。我们的研究结果表明丙戊酸和喹硫平可能具有神经保护作用。 (c) 2006 Elsevier Ltd. 保留所有权利。
In patients with bipolar disorder, recent brain imaging studies have reported cingulate cortex volume change. We performed a volumetric magnetic resonance imaging (MRI) study to assess the subregions of the cingulate gyrus; left anterior cingulate (LAC), left posterior cingulate (LPC), right anterior cingulate (RAC), and right posterior cingulate (RPC). Our sample consisted of bipolar patients that are either unmedicated (n = 10), on valproate monotherapy (n = 10) or on valproate plus quetiapine (n = 10) versus healthy comparisons (n = 10). Thirty right-handed bipolar disordered patients were recruited. Of them, 10 were first-applying patients who never had taken any drug for this,condition (medication-naive group), 10 were on valproate treatment (valproate group) and 10 were on valproate plus quetiapine treatment (valproate plus quetiapine group). Cingulate gyrus volumes included both cortex and white matter. Drug-free patients had significantly smaller LAC and LPC volumes compared with valproate and valproate plus quetiapine groups and healthy controls. In addition, in post hoc comparisons, a trend toward significant difference was found between valproate plus quetiapine group and valproate group in regard to only LAC. Our findings suggest that valproate and quetiapine may have neuroprotective effects. (c) 2006 Elsevier Ltd. All rights reserved.