PROD-screen - a screen for prodromal symptoms of psychosis
PROD-screen - a screen for prodromal symptoms of psychosis
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DOI：
10.1002/mpr.146
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发表时间：
2003-01-01
影响因子：
3.1
通讯作者：
McGlashan, TH
中科院分区：
文献类型：
--
作者：
Heinimaa, M;Salokangas, RKR;McGlashan, TH
本研究旨在描述PROD - 筛查量表，这是一种用于筛查预示近期精神病转化风险的前驱症状的工具。PROD - 筛查量表由29个评估表现和症状的问题组成。通过比较来自未筛选的普通人群（GP，n = 64）与来自社区精神卫生中心的普通精神病患者（CMHC，n = 107）的得分，对临床结构效度进行了测试。在一个大型的流行病学混合研究对象样本（n = 132）中，通过将PROD - 筛查量表得分与作为金标准的前驱症状结构化访谈所做出的前驱诊断进行比较，评估了PROD - 筛查量表对精神病前驱症状的一致性效度。使用21 - 12个特定症状的分界点，PROD - 筛查量表在77%的病例中对前驱状态进行了正确分类，在流行病学混合样本中以前驱者与非前驱者区分时具有合理的敏感性（80%）和特异性（75%）。根据子样本分析，PROD - 筛查量表在精神分裂症患者的一级亲属中效果良好，可能在普通人群样本中也是如此，但在精神科门诊患者中效果不佳。总之，PROD - 筛查量表是一种用于筛查精神病前驱症状以及选择受试者进行更广泛研究访谈的有用工具。
The aim of this study was to describe the PROD-screen, an instrument for screening prodromal symptoms indicating risk for psychotic conversion in the near future. PROD-screen consists of 29 questions assessing performance and symptoms.Clinical construct validity was tested by comparing scores from the unselected general population (GP, n = 64) with those of general psychiatric patients from a community mental health centre (CMHC, n = 107). The concordant validity of PROD-screen for prodromal symptoms of psychosis was assessed in a large epidemiologically mixed sample of research subjects (n = 132) by comparing PROD-screen scores with the prodromal diagnosis made by Structured Interview for Prodromal Symptoms as a gold standard.Using the cut-off point of 2112 specific symptoms, PROD-screen gave correct classification of prodromal status in 77% of cases, distinguishing prodromal from non-prodromal subjects with reasonable sensitivity (80%) and specificity (75%) in the epidemiologically mixed sample. According to subsample analysis PROD-screen functions well with first-degree relatives of schizophrenic patients and probably also with general population samples, but not with psychiatric outpatients.In conclusion, PROD-screen is a useful tool for screening prodromal symptoms of psychosis and selecting subjects for more extensive research interviews.