Depressive symptomatology, psychological stress, and ovarian reserve: a role for psychological factors in ovarian aging?
Depressive symptomatology, psychological stress, and ovarian reserve: a role for psychological factors in ovarian aging?
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DOI：
10.1097/gme.0b013e31825540d8
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Cedars MI
中科院分区：
文献类型：
--
作者：
Bleil ME;Adler NE;Pasch LA;Sternfeld B;Gregorich SE;Rosen MP;Cedars MI
在卵巢老化（OVA）研究中，对683名绝经前妇女的多种族样本进行了研究，以检查与卵巢储备标志物——心房卵泡计数（AFC）相关的心理因素。在横断面分析中，进行了线性回归，以确定女性AFC下降是否随抑郁水平以及抑郁与心理压力的结合而变化。采用流行病学研究中心抑郁量表（CESD）总分和子量表得分测量抑郁，采用感知压力量表测量心理压力。协变量调整后，年龄-x积极情绪的双向交互作用和年龄-x积极情绪-x压力的三向交互作用与AFC相关（b = 0.047, p = 0.036; b = 0.012, p = 0.099）。在分层分析中，应激与低积极情绪女性的AFC相关（b =−）。070, p = .021)，但在高度积极影响的女性中没有（b = .018, p = .54）。在报告低（- 0.747卵泡/年）、中（- 0.920卵泡/年）和高（- 1.112卵泡/年）压力水平的女性中，AFC下降程度逐渐升高。检查CESD总分和剩余分量表得分的结果均无统计学意义（p < 0.05）。横断面证据表明：1)低积极情绪可能加速AFC下降；2)低积极情绪可能是一个脆弱因素，或者，高积极情绪可能是一个保护因素，在调节心理应激对AFC下降的负面影响。
To examine psychological factors in relation to antral follicle count (AFC), a marker of ovarian reserve, in a multiethnic sample of 683 pre-menopausal women in the Ovarian Aging (OVA) Study. In cross-sectional analyses, linear regression was performed to determine whether AFC decline across women varied over levels of depression as well as depression in combination with psychological stress. The total and subscale scores of the Center for Epidemiological Studies Depression Scale (CESD) were used to measure depression and the Perceived Stress Scale was used to measure psychological stress. Following covariate-adjustment, the 2-way interaction of age-x-positive affect and the 3-way interaction of age-x-positive affect-x-stress were related to AFC (b = 0.047, p = .036; b = 0.012, p = .099, respectively). In stratified analyses, stress was related to AFC in women with low positive affect (b = −.070, p = .021) but not in women with high positive affect (b = .018, p = .54). AFC decline across women was progressively higher in women with low positive affect who reported low (−0.747 follicles/year), mid (−0.920 follicles/year), and high (−1.112 follicles/year) levels of stress. Results examining the CESD total and remaining subscale scores were all non-significant (p’s > .05). Cross-sectional evidence suggests that 1) women with low positive affect may experience accelerated AFC decline and 2) low positive affect may be a vulnerability factor, or, alternatively, high positive affect may be a protective factor, in moderating the negative effects of psychological stress on AFC decline.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
4.6
作者：
Harkness, Kate L.;Alavi, Nazanin;Monroe, Scott M.;Slavich, George M.;Gotlib, Ian H.;Bagby, R. Michael
通讯作者：
Bagby, R. Michael
影响因子：
6.1
作者：
Hansen, Karl R.;Knowlton, Nicholas S.;Klein, Nancy A.
通讯作者：
Klein, Nancy A.
影响因子：
7.6
作者：
Almeida, DM;Kessler, RC
通讯作者：
Kessler, RC
影响因子：
6.9
作者：
Blazer, DG;Landerman, LR;Saunders, WB
通讯作者：
Saunders, WB