Roles and Mechanisms of Obstructive Sleep Apnea-Hypopnea Syndrome and Chronic Intermittent Hypoxia in Atherosclerosis: Evidence and Prospective.
Roles and Mechanisms of Obstructive Sleep Apnea-Hypopnea Syndrome and Chronic Intermittent Hypoxia in Atherosclerosis: Evidence and Prospective.
复制标题
阻塞性睡眠呼吸暂停低通气综合征和慢性间歇性缺氧在动脉粥样硬化中的作用和机制：证据和展望
DOI：
10.1155/2016/8215082
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发表时间：
2016
影响因子：
--
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Ma L;Zhang J;Liu Y
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的发病率和死亡率被认为是其对心血管系统的不良影响的后果。OSAHS引起的慢性间歇性缺氧（CIH）可导致血管内皮损伤，从而促进动脉粥样硬化（AS）的发展。研究表明CIH是AS发生发展的独立危险因素，但其潜在机制尚不清楚。本文就近10年来CIH介导的AS发生发展的临床和基础研究进行综述，主要涉及炎症、氧化应激、胰岛素抵抗、细胞凋亡、血管内皮损伤、血小板活化和神经内分泌紊乱等方面。本综述将为研究者制定有效的OSAHS相关心脑血管疾病的干预策略提供现有的证据和观点。
The morbidity and mortality of obstructive sleep apnea-hypopnea syndrome (OSAHS) are regarded as consequences of its adverse effects on the cardiovascular system. Chronic intermittent hypoxia (CIH) induced by OSAHS can result in vascular endothelial injury, thus promoting development of atherosclerosis (AS). Studies have shown that CIH is an independent risk factor for the occurrence and development of AS, but the underlying mechanism remains unclear. Here, we review clinical and fundamental studies reported during the last 10 years on the occurrence and development of AS mediated by CIH, focusing on inflammation, oxidative stress, insulin resistance, cell apoptosis, vascular endothelial injury, platelet activation, and neuroendocrine disorders. This review will offer current evidence and perspective to researchers for the development of effective intervention strategies for OSAHS-related cardiocerebrovascular diseases.