In vitro gender differences in neuronal survival on hypoxia and in 17β-estradiol-mediated neuroprotection
In vitro gender differences in neuronal survival on hypoxia and in 17β-estradiol-mediated neuroprotection
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DOI：
10.1038/sj.jcbfm.9600056
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发表时间：
2005-04-01
影响因子：
6.3
通讯作者：
Ehrenreich, H
中科院分区：
文献类型：
--
作者：
Heyer, A;Hasselblatt, M;Ehrenreich, H
神经精神疾病的性别差异已得到确认，但尚未得到很好的理解。研究了培养大鼠海马原代神经元的存活率，我们发现在正常缺氧和低氧条件下存在显著的性别差异。正常氧条件下，雄性细胞的抗氧能力强于雌性细胞，而在低氧条件下，雄性细胞的抗氧能力强于雌性细胞。男性的脆弱性模式是在新生儿睾酮启动的女性细胞中获得的。雌激素通过膜受体起作用，在男性神经元中具有更高的神经保护能力，这至少部分解释了只有在男性细胞缺氧时雌激素受体β / α比值的显著增加。
Gender differences in neuropsychiatric disease are recognized but not well understood. Investigating the survival of primary rat hippocampal neurons in culture, we found significant and inverted gender differences on normoxia versus hypoxia. Male cells were more resistant under normoxia but more vulnerable under hypoxia than female cells. Male vulnerability pattern was acquired in cells from neonatally testosterone-primed females. Estrogens, acting via membrane receptors, had a higher neuroprotective power in male neurons, explained at least in part by the pronounced increase in estrogen receptor beta/alpha ratio during hypoxia in male cells only.