Effects of methylphenidate on attentional function after traumatic brain injury. A randomized, placebo-controlled trial.
Effects of methylphenidate on attentional function after traumatic brain injury. A randomized, placebo-controlled trial.
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哌醋甲酯对脑外伤后注意力功能的影响。
DOI：
10.1097/00002060-199711000-00002
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发表时间：
1997
影响因子：
3
通讯作者：
Coslett,HB
中科院分区：
文献类型：
--
作者：
Whyte,J;Hart,T;Schuster,K;Fleming,M;Polansky,M;Coslett,HB
创伤性脑损伤(TBI)后的注意力缺陷是常见的和致残的。许多药物已被用来改善注意力缺陷，而哌酸甲酯(MP)因其在注意缺陷障碍中的疗效而引起了人们的极大兴趣。然而，MP在脑外伤患者中的临床研究结果喜忧参半。我们考察了MP对脑外伤患者注意功能的影响，这些患者是专门进行注意力评估和治疗的。受试者采用双盲、安慰剂对照、重复交叉设计，使用五种不同的任务来测量注意力功能的各个方面。MP显著提高了心理加工的速度。对于分心，持续注意力的大部分方面，以及对运动速度的测量都没有受到影响。这些结果表明，MP对脑外伤可能是一种有用的治疗方法，但主要用于可归因于精神加工减慢的症状。
Attention deficits after traumatic brain injury (TBI) are common and disabling. Many pharmacologic agents have been used to ameliorate attention deficits, and considerable interest has focused on methylphenidate (MP) because of its documented efficacy in attention deficit disorder. However, clinical studies of MP in subjects with TBI have yielded mixed results. We examined the effects of MP on attentional function in individuals with TBI referred specifically for attentional assessment and treatment. Subjects were studied in a double-blind, placebo-controlled, repeated crossover design, using five different tasks designed to measure various facets of attentional function. MP produced a significant improvement in the speed of mental processing. Orienting to distractions, most aspects of sustained attention, and measures of motor speed were unaffected. These results suggest that MP may be a useful treatment in TBI but is primarily useful for symptoms that can be attributed to slowed mental processing.