Part III. Chemistry, host entry, and metabolic fate of carcinogens
Part III. Chemistry, host entry, and metabolic fate of carcinogens
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第三部分。
DOI：
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发表时间：
1963
期刊：
影响因子：
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通讯作者：
P. Kotin
中科院分区：
文献类型：
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作者：
H. Falk;P. Kotin
皮肤、呼吸道和胃肠道是环境致癌物质进入宿主的器官系统。在致癌物质的几个来源中，本报告涉及呼吸环境中最常见的两种-城市污染的空气和香烟烟雾。致癌的多环芳烃（PAH）是最普遍存在的，并且浓度最高。某些外源性和内源性因素显著地改变致癌碳氢化合物的生物作用。外源性因素包括：（1）环境中抗癌剂的同时存在和作用，（2）它们以与呼吸道吸入和沉积相容的物理状态出现，（3）存在改变宿主反应的因素，特别是与正常生理防御有关的因素。内生因素包括：（1）作为致癌剂的媒介物，因为它影响进入部位的持久性和全身分布速率，（2）肝胆系统的代谢速率，和（3）存在改变组织反应的解剖或代谢异常。
The skin, respiratory tract, and gastrointestinal tract are the organ systems through which environmental carcinogenic agents gain entry into the host. Of the several sources of carcinogenic agents, this report is concerned with the two most common in the respiratory environment—urban polluted air and cigarette smoke. Carcinogenic polycyclic aromatic hydrocarbons (PAH) are the most ubiquitous and are present in the highest concentrations. Certain exogenous and endogenous factors significantly modify the biologic action of carcinogenic hydrocarbons. Exogenous factors includes (1) the simultaneous presence and action of anticarcinogenic agents in the environment, (2) their occurrence in a physical state compatible with inhalation and deposition in the respiratory tract, and (3) the presence of factors modifying the host response, particularly in relation to the normal physiologic defenses. The endogenous factors include: (1) the vehicle serving the carcinogenic agents as it affects persistence at site of entry and rate of systemic distribution, (2) the rate of metabolism in the hepatobiliary system, and (3) the existence of anatomic or metabolic abnormalities modifying the tissue response.