Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice
Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice
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DOI：
10.1016/j.bbrc.2007.04.170
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发表时间：
2007-07-06
影响因子：
3.1
通讯作者：
Yokode, Masayuki
中科院分区：
文献类型：
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作者：
Harauma, Akiko;Murayama, Toshinori;Yokode, Masayuki
桑葚常用来喂蚕。在这里，我们研究了膳食中摄入桑叶 (ML) 是否会影响体内和体外动脉粥样硬化形成。载脂蛋白 E 缺陷小鼠从 6 周龄开始喂食正常食物（对照组）或含有 1% ML 粉末的饮食（ML 组）。 12周后处死小鼠。使用二烯形成评估血浆脂蛋白对氧化的敏感性。与对照组相比，ML 组脂蛋白氧化的滞后时间显着增加。此外，与对照组相比，ML 组的主动脉粥样硬化病变大小减少了 40%。我们还检测了 ML 的体外直接抗氧化活性。 ML水提取物对1,1-二苯基-2-三硝基苯肼有很强的清除作用，并抑制脂蛋白氧化。这些结果证实，ML 含有抗氧化物质，可能有助于预防动脉粥样硬化。 (c) 2007 Elsevier Inc. 保留所有权利。
Mulberry is commonly used to feed silkworms. Here we examined whether a dietary intake of mulberry leaf (ML) could affect atherogenesis in vivo and in vitro. Apolipoprotein E-deficient mice were fed either normal chow (control group) or a diet containing 1% ML powder (ML group) from 6 weeks of age. The mice were sacrificed after 12 weeks. The susceptibility of plasma lipoprotein to oxidation was assessed using diene formation. A significant increase in the lag time of lipoprotein oxidation was detected in the ML group compared with the control group. Furthermore, the ML group showed a 40% reduction in atherosclerotic lesion size in the aortae compared with the control. We also examined the direct anti-oxidative activity of ML in vitro. Aqueous extract of ML had a strong scavenging effect on 1,1-diphenyl-2-picrylhydrazyl and inhibited lipoprotein oxidation. These results confirm that ML contains anti-oxidative substances that might help prevent atherosclerosis. (c) 2007 Elsevier Inc. All rights reserved.