Platelet-Derived Growth Factor Receptor Alpha as a Marker of Mesenchymal Stem Cells in Development and Stem Cell Biology.
Platelet-Derived Growth Factor Receptor Alpha as a Marker of Mesenchymal Stem Cells in Development and Stem Cell Biology.
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DOI：
10.1155/2015/362753
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发表时间：
2015
影响因子：
4.3
通讯作者：
Xaymardan M
中科院分区：
文献类型：
--
作者：
Farahani RM;Xaymardan M
三十年来，间充质干细胞(MSCs)在实验室得到了广泛的研究和临床应用。然而，关于它们的解剖位置、身份、功能和分化能力的程度仍然存在歧义。进行MSC研究的主要障碍之一是缺乏合适的体内标志物。近年来，随着PDGFRα作为一种重要的间充质干细胞标记物的出现，这一障碍在一定程度上得到了解决。越来越多的证据表明，PDGFRα+细胞存在于许多成人间质的血管周围位置，在体外和体内都符合MSCs的经典概念。长期以来，人们一直认为PDGFRα在胚胎发育过程中对中胚层的形成和结缔组织的发育具有重要作用。目前的综述描述了有关PDGFRα在形态发生和分化中的作用及其对间充质干细胞生物学的影响的证据。
Three decades on, the mesenchymal stem cells (MSCs) have been intensively researched on the bench top and used clinically. However, ambiguity still exists in regard to their anatomical locations, identities, functions, and extent of their differentiative abilities. One of the major impediments in the quest of the MSC research has been lack of appropriate in vivo markers. In recent years, this obstacle has been resolved to some degree as PDGFRα emerges as an important mesenchymal stem cell marker. Accumulating lines of evidence are showing that the PDGFRα + cells reside in the perivascular locations of many adult interstitium and fulfil the classic concepts of MSCs in vitro and in vivo. PDGFRα has long been recognised for its roles in the mesoderm formation and connective tissue development during the embryogenesis. Current review describes the lines of evidence regarding the role of PDGFRα in morphogenesis and differentiation and its implications for MSC biology.