The etiology of severe anemia in a village and a periurban area in Mali
The etiology of severe anemia in a village and a periurban area in Mali
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DOI：
10.1182/blood-2003-11-3884
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发表时间：
2004-08-15
期刊：
影响因子：
20.3
通讯作者：
Miller, LH
中科院分区：
文献类型：
--
作者：
Dicko, A;Klion, AD;Miller, LH
严重贫血是非洲疟疾的主要并发症之一。我们研究了两个人群，一个在村庄，另一个在马里的城郊地区，以了解疾病的可预防因素。疾病的2个相关因素是每微升寄生红细胞超过10万个（0.1 × 10(12)/L）和低基线血红蛋白水平。所有中度至重度贫血病例均发生在3.2岁以下儿童中。提高血红蛋白基线水平和降低婴幼儿寄生虫血症峰值可减少疟疾感染引起的严重贫血的发生率。(C) 2004年由美国血液病学会出版。
Severe anemia is one of the major complications of malaria in Africa. We studied 2 populations, one in a village and the second in a periurban area in Mali, to understand the preventable factors in the disease. The 2 correlates of disease were parasitemia above 100 000 parasitized red blood cells per microliter (0.1 x 10(12)/L) and a low baseline hemoglobin level. All cases of moderate to severe anemia occurred in children under 3.2 years of age. Raising the baseline hemoglobin level and lowering peak parasitemia in infants and young children may reduce the incidence of severe anemia resulting from malarial infection. (C) 2004 by The American Society of Hematology.