Selectivity of kainic acid as a neurotoxin within the dorsal lateral geniculate nucleus of the cat: a model for transneuronal retrograde degeneration.
Selectivity of kainic acid as a neurotoxin within the dorsal lateral geniculate nucleus of the cat: a model for transneuronal retrograde degeneration.
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红藻氨酸作为猫背外侧膝状核内神经毒素的选择性：跨神经元逆行变性模型。
DOI：
10.1007/bf01355534
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Stoffler,DJ
中科院分区：
文献类型：
--
作者：
Pearson,HE;Sonstein,WJ;Stoffler,DJ
注射细胞毒素kainic酸对成年猫膝状背外侧核进行局部损伤，以建立研究突触后靶丢失影响的模型。Kainic acid Kainic acid Kainic acid Kainic acid Kainic acid Kainic acid Kainic acid Kainic acid Kainic acid然而，kainic酸的选择性一直受到质疑，因为它也可能影响传入终端或传递轴突。用辣根过氧化物酶顺行标记和电镜观察，观察海碱盐注射1周后视网膜向变性膝状核的投影。结果表明，在神经元丢失区域内存在传入终端，因此kainic酸对固有膝状神经元具有选择性。
In situinjections of the cytotoxin kainic acid were used to make localized lesions of the dorsal lateral geniculate nucleus in the adult cat to produce a model for studying the effects of postsynaptic target loss. Kainic acid has been used extensively to produce lesions of neuronal cell bodies within the central nervous system. However, the selectivity of kainic acid has been questioned, as it may also affect afferent terminals or axons of passage. Retinal projections to degenerated geniculate nuclei were visualized 1 week after kainate injection using anterograde labelling with horseradish peroxidase and electron microscopy. The results demonstrate the presence of afferent terminals within regions of neuronal loss, and hence the selectivity of kainic acid for intrinsic geniculate neurons.