APPLICATION OF HYGROMYCIN A STRUCTURE-ACTIVITY-RELATIONSHIPS TO THE ANTIBIOTIC A201A
APPLICATION OF HYGROMYCIN A STRUCTURE-ACTIVITY-RELATIONSHIPS TO THE ANTIBIOTIC A201A
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DOI：
10.1016/s0960-894x(01)80896-9
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发表时间：
1993-02-01
影响因子：
2.7
通讯作者：
WERNER, KM
中科院分区：
文献类型：
--
作者：
HECKER, SJ;LILLEY, SC;WERNER, KM
用烯丙基醚代替A201 A的二糖部分，伴随着3-羟基化，提供了具有与天然产物相当的生物活性的类似物。生物活性对这种修饰的反应与潮霉素A观察到的反应密切相似，这意味着这两种天然产物可能具有共同的结合位点。
Replacement of the disaccharide portion of A201A with an allyl ether, with concomitant 3-hydroxylation, affords an analog with biological activity comparable to that of the natural product. The response of biological activity to this modification closely parallels that observed with hygromycin A, which implies that these two natural products may share a common binding site.