A Quinoline Antibiotic from Rhodococcus erythropolis JCM 6824
A Quinoline Antibiotic from Rhodococcus erythropolis JCM 6824
复制标题
DOI：
10.1038/ja.2008.96
复制
发表时间：
2008-11-01
影响因子：
3.3
通讯作者：
Tamura, Tomohiro
中科院分区：
文献类型：
--
作者：
Kitagawa, Wataru;Tamura, Tomohiro
从红红红球菌JCM 6824培养液中分离鉴定了一种新的喹啉类抗生素aurachin RE。通过核磁共振和质谱分析确定了金桃红素的RE结构。其结构与从金刺茅中鉴定出的aurachin C抗生素相似。然而，与aurachin C相比，aurachin RE对高gc和低gc革兰氏阳性菌均表现出广泛而强的抗菌谱。
A new quinoline antibiotic, aurachin RE, was isolated and identified from a culture broth of Rhodococcus erythropolis JCM 6824. The aurachin RE structure was determined based on NMR and mass spectrometric analysis. The structure is similar to that of aurachin C antibiotics that have been identified from Stigmatella aurantiaca. Compared to aurachin C, however, aurachin RE exhibits a wide and strong antimicrobial spectrum against both high- and low-GC Gram-positive bacteria.