STEREOCHEMISTRY OF PALYTOXIN. PART 4. COMPLETE STRUCTURE
STEREOCHEMISTRY OF PALYTOXIN. PART 4. COMPLETE STRUCTURE
复制标题
海藻毒素的立体化学。
DOI：
10.1002/chin.198312364
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Y. Hirata
中科院分区：
文献类型：
--
作者：
J. Cha;W. Christ;J. M. Finan;H. Fujioka;Y. Kishi;L. L. Klein;S. Ko;J. Leder;W. Mcwhorter;K. Pfaff;M. Yonaga;D. Uemura;Y. Hirata
(2)我们在前面的交流中讨论过的一些降解产物是通过与羰基相邻的不对称中心的中间体制备的，例如，在第3部分中由1制备17。在制备和/或分离这些降解产物的过程中，这些不对称中心发生外聚化的可能性被排除在每个案例的仔细对照实验中。(3)参见本系列第1部分中的参考文献2a-f。(4)参见本系列第1部分的参考资料。(5)孢毒素* H NMR谱的烯烃区几乎为一级。观察到以下自旋-自旋耦合常数（Hz）：
(2) Some degradation products that we have dealt with inthe preceding communications were prepared via intermediates with asymmetric centers adjacent to carbonyl groups, eg, preparation of 17 from 1 in part 3. The possibility that epimerization of these asymmetric centers occurred during preparation and/or isolation of these degradation products was excluded by careful control experiments for each case.(3) See ref 2a-f in part 1 of this series.(4) See ref la-e in part 1 of this series.(5) The olefinic region of the* H NMR spectrum of palytoxin was virtually first order. The following spin-spin coupling constants (Hz) were observed: