Methotrexate and rheumatoid arthritis associated interstitial lung disease.
Methotrexate and rheumatoid arthritis associated interstitial lung disease.
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甲氨蝶呤与类风湿性关节炎相关的间质性肺病。
DOI：
10.1183/13993003.00337-2020
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Dieudé P
中科院分区：
文献类型：
--
作者：
Juge PA;Lee JS;Lau J;Kawano-Dourado L;Rojas Serrano J;Sebastiani M;Koduri G;Matteson E;Bonfiglioli K;Sawamura M;Kairalla R;Cavagna L;Bozzalla Cassione E;Manfredi A;Mejia M;Rodríguez-Henriquez P;González-Pérez MI;Falfán-Valencia R;Buendia-Roldán I;Pérez-Rubio G;Ebstein E;Gazal S;Borie R;Ottaviani S;Kannengiesser C;Wallaert B;Uzunhan Y;Nunes H;Valeyre D;Saidenberg-Kermanac'h N;Boissier MC;Wemeau-Stervinou L;Flipo RM;Marchand-Adam S;Richette P;Allanore Y;Dromer C;Truchetet ME;Richez C;Schaeverbeke T;Lioté H;Thabut G;Deane KD;Solomon JJ;Doyle T;Ryu JH;Rosas I;Holers VM;Boileau C;Debray MP;Porcher R;Schwartz DA;Vassallo R;Crestani B;Dieudé P
Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of RA. Whether MTX exposure increases the risk of ILD in patients with RA is disputed. We aimed to evaluate the association of prior MTX use with development of RA-ILD. Through a case–control study design with discovery and international replication samples, we examined the association of MTX exposure with ILD in 410 patients with chronic fibrotic ILD associated with RA (RA-ILD) and 673 patients with RA without ILD. Estimates were pooled over the different samples using meta-analysis techniques. Analysis of the discovery sample revealed an inverse relationship between MTX exposure and RA-ILD (adjusted OR 0.46, 95% CI 0.24–0.90; p=0.022), which was confirmed in the replication samples ( pooled adjusted OR 0.39, 95% CI 0.19–0.79; p=0.009). The combined estimate using both the derivation and validation samples revealed an adjusted OR of 0.43 (95% CI 0.26–0.69; p=0.0006). MTX ever-users were less frequent among patients with RA-ILD compared to those without ILD, irrespective of chest high-resolution computed tomography pattern. In patients with RA-ILD, ILD detection was significantly delayed in MTX ever-users compared to never-users (11.4±10.4 years and 4.0±7.4 years, respectively; p<0.001). Our results suggest that MTX use is not associated with an increased risk of RA-ILD in patients with RA, and that ILD was detected later in MTX-treated patients.
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影响因子：
3.7
作者：
Hyldgaard, Charlotte;Ellingsen, Torkell;Bendstrup, Elisabeth
通讯作者：
Bendstrup, Elisabeth
影响因子：
5
作者：
CARSON, CW;CANNON, GW;CLEGG, DO
通讯作者：
CLEGG, DO
DOI：
10.1056/nejmoa1801562
发表时间：
2018-12-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Juge PA;Lee JS;Ebstein E;Furukawa H;Dobrinskikh E;Gazal S;Kannengiesser C;Ottaviani S;Oka S;Tohma S;Tsuchiya N;Rojas-Serrano J;González-Pérez MI;Mejía M;Buendía-Roldán I;Falfán-Valencia R;Ambrocio-Ortiz E;Manali E;Papiris SA;Karageorgas T;Boumpas D;Antoniou K;van Moorsel CHM;van der Vis J;de Man YA;Grutters JC;Wang Y;Borie R;Wemeau-Stervinou L;Wallaert B;Flipo RM;Nunes H;Valeyre D;Saidenberg-Kermanac'h N;Boissier MC;Marchand-Adam S;Frazier A;Richette P;Allanore Y;Sibilia J;Dromer C;Richez C;Schaeverbeke T;Lioté H;Thabut G;Nathan N;Amselem S;Soubrier M;Cottin V;Clément A;Deane K;Walts AD;Fingerlin T;Fischer A;Ryu JH;Matteson EL;Niewold TB;Assayag D;Gross A;Wolters P;Schwarz MI;Holers M;Solomon JJ;Doyle T;Rosas IO;Blauwendraat C;Nalls MA;Debray MP;Boileau C;Crestani B;Schwartz DA;Dieudé P
通讯作者：
Dieudé P
影响因子：
24.3
作者：
Imokawa, S;Colby, TV;Helmers, RA
通讯作者：
Helmers, RA
影响因子：
2.7
作者：
FIRTH, D
通讯作者：
FIRTH, D