INNERVATION OF PUTATIVE RAPIDLY ADAPTING MECHANORECEPTORS BY CALBINDIN-IMMUNOREACTIVE AND CALRETININ-IMMUNOREACTIVE PRIMARY SENSORY NEURONS IN THE RAT
INNERVATION OF PUTATIVE RAPIDLY ADAPTING MECHANORECEPTORS BY CALBINDIN-IMMUNOREACTIVE AND CALRETININ-IMMUNOREACTIVE PRIMARY SENSORY NEURONS IN THE RAT
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DOI：
10.1111/j.1460-9568.1994.tb00269.x
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发表时间：
1994-02-01
影响因子：
3.4
通讯作者：
DROZ, B
中科院分区：
文献类型：
--
作者：
DUC, C;BARAKATWALTER, I;DROZ, B
Calbindin和calretinin是两个同源的钙结合蛋白，在初级感觉神经元亚群中表达。在本研究中，我们研究了大鼠背根神经节中表达calbindin和calretinin的神经元的分布及其周围投射。Calbindin和calretinin的免疫反应性在大、小的初级感觉神经元亚群中表达，并在大多数大的感觉神经元中共定位。从calbindin-或calcalentin -免疫反应性神经元产生的轴突支配无毛皮肤的肌纺锤体、Pacini小体和表皮下板层小体，在毛发和触须周围形成披针形末梢的栅栏，并在指皮肤中产生表皮内神经末梢。由于大多数这些传入事件被认为是快速适应的机械感受器，因此可以得出结论，表达calbindin或calretinin的神经元支配特定的机械感受器，这些机械感受器表现出对刺激快速适应的生理特征。
Calbindin and calretinin are two homologous calcium-binding proteins that are expressed by subpopulations of primary sensory neurons. In the present work, we have studied the distribution of the neurons expressing calbindin and calretinin in dorsal root ganglia of the rat and their peripheral projections. Calbindin and calretinin immunoreactivities were expressed by subpopulations of large- and small-sized primary sensory neurons and colocalized in a majority of large-sized ones. The axons emerging from calbindin- or calretinin-immunoreactive neurons innervated muscle spindles, Pacini corpuscles and subepidermal lamellar corpuscles in the glabrous skin, formed palisades of lanceolate endings around hairs and vibrissae, and gave rise to intraepidermal nerve endings in the digital skin. Since most of these afferents are considered as rapidly adapting mechanoreceptors, it is concluded that calbindin- or calretinin-expressing neurons innervate particular mechanoreceptors that display physiological characteristics of rapid adaptation to stimuli.