Evolution of obesity in a low birth weight cohort
Evolution of obesity in a low birth weight cohort
复制标题
DOI：
10.1038/jp.2011.75
复制
发表时间：
2012-02-01
影响因子：
2.9
通讯作者：
Simpson, P. M.
中科院分区：
文献类型：
--
作者：
Casey, P. H.;Bradley, R. H.;Simpson, P. M.
目的：本研究的目的是确定低出生体重早产儿（LBWPT）至8岁的纵向队列中肥胖状态（OS）的演变，并确定出生后第一年的快速体重增加是否独立预测8年OS。总共有985名婴儿（出生体重2500克，孕龄37周）被招募从托儿所在8个站点的干预研究计划，并在3，5，6.5和8岁的年龄进行了评估。在每次访视时通过标准方案测量体重和身高，并计算体重指数。年龄和性别的肥胖状况>= 95%。对8年OS进行多因素logistic分析，预测变量包括婴儿种族、性别、小于胎龄儿状态、出生体重类别、新生儿健康指数。结果：总体而言，3岁时OS为2.3%，5岁时OS为6.1%，6.5岁时OS为7.7%，8岁时OS为8.7%。每次访视时，OS因出生体重类别而异。出生时体重1500 g的婴儿在各年龄段的OS患病率最低。在逻辑回归中，（西班牙裔）（校正比值比= 2.8，置信区间= 1.2至6.8），母亲肥胖状态（调整后的比值比3.4，置信区间= 1.5至7.8）和第一年体重增加（调整的比值比= 2.7，置信区间= 1.9至3.9），显着预测8年OS。结论：OS是常见的LBWPT婴儿在儿童期，患病率不同的出生体重类别。出生后第一年的高体重增加是LBWPT儿童OS发展的重要预测因子Journal of Perinatology（2012）32，91-96; doi：10.1038/jp.2011.75;在线发表6月9日
Objective: The objective of this study was to determine the evolution of obesity status (OS) in a longitudinal cohort of low birth weight preterm (LBWPT) infants to an age of 8 years, and to determine whether rapid weight gain in the first year of life independently predicts 8-year OS.Study Design: In total, 985 infants (birth weight 2500 g, gestation age 37 weeks) were recruited from the nursery in an eight-site intervention research program and were evaluated at an age of 3, 5, 6.5 and 8 years. Weight and height were measured by standard protocol at each visit and body mass index was calculated. Obesity status is >= 95% for age and sex. Multiple logistic analyses were performed on 8-year OS with predictor variables including infant race, gender, small for gestational age status, birth weight category, neonatal health index,. treatment group and first-year weight gain; maternal education and weight status before conception; and HOME Inventory.Result: Overall, 2.3% were OS at an age of 3 years, 6.1% at an age of 5 years, 7.7% at age 6.5 years and 8.7% at an age 8 years. OS varied by birth weight category at each visit. The infants born 1500 g had the lowest prevalence of OS at each age. In the logistic regression, maternal race (Hispanic) (adjusted odds ratio = 2.8, confidence interval = 1.2 to 6.8), maternal obese status (adjusted odds ratio 3.4, confidence interval = 1.5 to 7.8) and first-year weight gain (adjusted odds ratio = 2.7, confidence interval = 1.9 to 3.9), significantly predicted 8-year OS.Conclusion: OS is common in LBWPT infants during childhood, and prevalence varies by birth weight category. High weight gain in the first year of life is an important predictor of the development of OS in LBWPT children Journal of Perinatology (2012) 32, 91-96; doi:10.1038/jp.2011.75; published online 9 June