Development of an artificial vertebral body using a novel biomaterial, hydroxyapatite/collagen composite
Development of an artificial vertebral body using a novel biomaterial, hydroxyapatite/collagen composite
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DOI：
10.1016/s0142-9612(02)00126-6
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发表时间：
2002-10-01
期刊：
影响因子：
14
通讯作者：
Tanaka, J
中科院分区：
文献类型：
--
作者：
Itoh, S;Kikuchi, M;Tanaka, J
合成具有骨样纳米结构的羟基磷灰石：胶原（HAp/Col）复合材料，并将其成型。本研究的目的是在人工椎体系统中使用这种新型植入物进行颈椎前路融合。采用吸附rhBMP-2（400马克杯/毫升）的beagle犬6只，不吸附rhBMP-2的beagle犬9只进行前路融合。在rhbmp治疗组的3只狗。非rhbmp组的6只狗。用聚l -丙交酯钢板和2枚钛螺钉固定假体。13周后取出植入物，rhBMP(-)：钢板（-）组、rhBMP(-)：钢板（+）组和rhBMP(-)：钢板（+）组各3只狗。24周后，分别从rhBMP(-)：钢板（+）组和rhBMP(+)：钢板（+）组的3只狗身上取出植入物。组织学和影像学分析表明，由于大部分复合材料在13周内被吸收。rhbmp治疗可减少椎间距离，增强骨痂形成和骨桥，有效防止种植体塌陷。尽管前路钢板内固定效果不明显。吸附rhBMP-2的HAp/Col种植体可能是现有陶瓷在颈椎前路椎间融合中的合适替代品。(C) 2002 Elsevier Science Ltd.版权所有。
Hydroxyapatite:collagen (HAp/Col) composites having a bone-like nanostructure were synthesized and shaped into implants. This study was designed to develop,in artificial vertebra system using this novel implant for anterior fusion of the cervical spine. Anterior fusion was carried out on 6 beagle dogs with the implants adsorbing rhBMP-2 (400 mug/ml), and 9 dogs with the implants without rhBMP-2. In 3 dogs of the rhBMP-treated group. as well as 6 dogs of the non-rhBMP-treated group. the implant was fixed with a poly-L-lactide plate and 2 titanium screws. Implants were taken out after 13 weeks front each 3 dogs in the rhBMP(-):plate(-), rhBMP(-):plate(+) and rhBMP(-):plate(+) groups. Also, the implants were removed from each 3 dogs in the rhBMP(-):plate(+) and rhBMP(+):plate(+) groups after 24 weeks. Histological and radiographical analysis Suggested that since the larger part of the composite material was absorbed within 13 weeks. reduction of the intervertebral distance was caused, and that enhancement of callus formation and bone bridging by rhBMP-treatment, was effective to prevent collapse of the implant. even though an effect of anterior plate-fixation was not obvious. The HAp/Col implant adsorbing rhBMP-2 may be a suitable replacement for the existing ceramics in anterior interbody fusion of the cervical spine. (C) 2002 Elsevier Science Ltd. All rights reserved.