Polymorphisms in the 5-hydroxytryptamine receptor 3B gene are associated with heroin dependence in the Chinese Han population.
Polymorphisms in the 5-hydroxytryptamine receptor 3B gene are associated with heroin dependence in the Chinese Han population.
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5-羟色胺受体3B基因的多态性与中国汉族人群的海洛因依赖有关。
DOI：
10.1016/j.neulet.2016.10.033
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Wei Shuguang
中科院分区：
文献类型：
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作者：
Yin Fangyuan;Ji Yuanyuan;Zhang Jing;Guo Hao;Huang Xin;Lai Jianghua;Wei Shuguang
已有研究表明5-羟色胺受体3B（HTR 3B）通过调节奖赏通路中多巴胺（DA）的释放参与海洛因依赖，HTR 3B基因多态性可能在调节海洛因成瘾风险中发挥作用。为了确定海洛因依赖遗传易感性的标志物，我们使用多重SNaPshot技术在中国汉族人群中检测了海洛因依赖与HTR 3B基因的7个单核苷酸多态性（SNPs）之间的潜在关联。参与者包括418名海洛因依赖者和422名健康对照者。结果表明，HTR 3Brs 1176746和rs 1185027基因型在海洛因依赖者和健康对照者中的分布差异有统计学意义（均P = 0.004）。海洛因依赖组rs 1176746 GG和rs 1185027 AA基因型频率显著高于健康对照组，rs 1176746 GA和rs 1185027 AT基因型频率显著低于健康对照组。另一个SNP rs 10789970在海洛因依赖者和对照者之间的基因型分布中显示名义上显著的p值（p= 0.022）。这些结果提示HTR 3B基因多态性在中国汉族人群海洛因依赖中起重要作用，为进一步研究海洛因依赖的遗传学和神经生物学机制提供了有价值的信息。
Previous studies suggested that the 5-hydroxytryptamine receptor 3B (HTR3B) is involved in heroin dependence by modulating dopamine (DA) release in the reward pathway and that the genetic polymorphisms inHTR3Bplay plausible role in modulating the risk of developing heroin addiction. To identify markers that contribute to the genetic susceptibility to heroin dependence, we examined the potential associations between heroin dependence and 7 single nucleotide polymorphisms (SNPs) of theHTR3Bgene using multiplex SNaPshot technology in a Chinese Han population. Participants included 418 heroin-dependent subjects and 422 healthy controls. The results suggested that the genotype distribution ofHTR3Brs1176746 and rs1185027 were significantly different between heroin dependent subjects and healthy controls (bothp= 0.004). The frequency of the GG of rs1176746 and AA of rs1185027 genotype in heroin-dependent subjects were significantly higher than that of healthy controls, while the GA of rs1176746 and AT of rs1185027 genotype distributions were much lower. Another SNP, rs10789970, showed a nominally significantp-value in the genotype distribution between heroin dependent subjects and controls (p= 0.022). These findings indicate the important role ofHTR3Bpolymorphisms in heroin dependence among the Chinese Han population and provide valuable information for further genetic and neurobiological investigations of heroin dependence.