Mitochondrial class II introns encode proteins related to the reverse transcriptases of retroviruses
Mitochondrial class II introns encode proteins related to the reverse transcriptases of retroviruses
复制标题
线粒体 II 类内含子编码与逆转录病毒逆转录酶相关的蛋白质
作者：
F. Michel;B. Lang
细胞器内含子有几个独特的特征，使它们与核编码的前信使rna中的对应子区别开来（参见文献1）：(1)它们的末端不服从GU…AG规则；(2)内含子是“结构化的”(同一家族或“类”的成员理论上可以采用非常相似的RNA二级构象1 - 3，并且对剪接突变体及其反射体的研究已经证实了几种假设的配对（例如，参见参考文献4）；(3)两个类的许多内含子都包含很长的开放阅读框架5 - 10。我们在这里报道了四个II类内含子潜在编码的蛋白质与病毒和转座因子起源的几种rna依赖性聚合酶有关。
Organelle introns share several distinctive features that set them apart from their counterparts in nuclear-encoded pre-messenger RNAs (reviewed in ref. 1): (1) their termini do not obey the GU… AG rule; (2) the introns are ‘structured’ (members of the same family or ‘class’ can theoretically adopt very similar RNA secondary conformations1–3 and several of the postulated pairings have been confirmed by studies of splicing mutants and their revertants (see, for example, ref. 4); (3) many introns from both classes contain long open reading frames5–10. We report here that the proteins potentially encoded by four class II introns are related to several RNA-dependent polymerases of viral and transposable element origins.
DOI：
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发表时间：
1980
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Nobrega,FG;Tzagoloff,A
通讯作者：
Tzagoloff,A