Camelid and shark single domain antibodies: structural features and therapeutic potential
Camelid and shark single domain antibodies: structural features and therapeutic potential
复制标题
DOI：
10.1016/j.sbi.2016.10.019
复制
发表时间：
2017-08-01
影响因子：
6.8
通讯作者：
Kolmarl, Harald
中科院分区：
文献类型：
--
作者：
Koenning, Doreen;Zielonka', Stefan;Kolmarl, Harald
除了由重链和轻链组成的典型抗体外，骆驼和软骨鱼的获得性免疫系统还包括不含轻链的仅重链亚型(HcAb)，其中抗原结合仅由一个可变区介导。由于其固有的有利属性，如对其同源抗原的高亲和力和特异性，非凡的稳定性，小的体积，以及最重要的是，在可药物的靶空间方面可以补充经典抗体，HcAb来源的实体逐渐成为生物医学应用的有前途的候选实体，其中许多已经被证明在早期临床试验中是成功的。
In addition to canonical antibodies composed of heavy and light chains, the adaptive immune systems of camelids and cartilaginous fish comprise heavy-chain only isotypes (HcAb) devoid of light chains, where antigen-binding is mediated exclusively by one variable domain. Due to their inherent favorable attributes, such as high affinity and specificity for their cognate antigen, extraordinary stability, small size and, most importantly, the possibility to complement classical antibodies in terms of 'drugable' target-space, HcAb-derived entities evolved as promising candidates for biomedical applications of which many have already proven to be successful in early stage clinical trials.