BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration
BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration
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DOI：
10.1016/j.medengphy.2010.07.010
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发表时间：
2010-11-01
影响因子：
2.2
通讯作者：
Kaplan, David L.
中科院分区：
文献类型：
--
作者：
Hechavarria, Daniel;Dewilde, Abiche;Kaplan, David L.
先前对脊椎动物肢体再生的研究表明，在再生过程中有几种介导因素参与，这些因素包括生物化学和生物物理两方面，而成年肢体再生现象并不是在哺乳动物物种中自然发生的，先前的研究主要集中在刺激组织生长和再生的生化模式上生物物理和生化因素对哺乳动物组织再生的影响BioDome是一个多组分的套管组件，它包含了小鼠截肢手指的伤口部位，并提供了一个有利于组织再生的环境。研究表明，当与猪膀胱基质（UBM）胃蛋白酶消化和电刺激结合使用时，BioDome在支持小鼠手指尖端再生的早期阶段是有效的电刺激和药物治疗的应用对再生产生了额外的影响(C) 2010 ipm由Elsevier Ltd出版版权所有
Previous research on vertebrate limb regeneration indicates there are several mediating factors involved during the re-growth process These factors are both biochemical and biophysical While the phenomenon of adult limb regeneration does not occur naturally in mammalian species prior research has focused mainly on biochemical modes of stimulating tissue growth and regeneration The BioDome was aimed at developing a new experimental tool to permit the more systematic study of the impact of biophysical and biochemical factors on mammalian tissue regeneration The BioDome is a multi-component sleeve assembly that encompasses the wound site of an amputated murine digit and provides an environment conducive to tissue regeneration The studies showed that the BioDome was effective in supporting early stages of murine digit tip regeneration when combined with a porcine urinary bladder matrix (UBM) pepsin digest and electrical stimulation The hydrated Inner environment of the BioDome influenced regeneration with additional effects seen with the application of electrical stimulation and pharmacological treatments (C) 2010 IPEM Published by Elsevier Ltd All rights reserved