Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist
Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist
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DOI：
10.1016/j.euroneuro.2005.10.003
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发表时间：
2006-05-01
影响因子：
5.6
通讯作者：
Celada, P
中科院分区：
文献类型：
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作者：
Díaz-Mataix, L;Artigas, F;Celada, P
5-HT1A 受体激动剂可增加腹侧被盖区 (VTA) 多巴胺 (DA) 神经元的活性以及内侧前额叶皮质 (mPFC) 中 DA 的释放。 mPFC 富含 5-HT1A 受体，并投射到中皮质多巴胺能神经元起源的 VTA。我们检查了 5-HT1A 受体激活是否可以调节投射到 VTA 的 mPFC 锥体神经元的活动。这些是通过 VTA 的逆向刺激来识别的，并在麻醉的大鼠中进行细胞外记录。选择性 5-HT1A 激动剂 BAY x 3702（10-80 μg/kg 静脉注射）增加了 14/19 个神经元（283 +/- 79%）的放电率，并降低了 5/19 个神经元（22 +/- 11%）的活性，导致放电率总体增加了 2.2 倍。这两种效应均被选择性 5-HT1A 拮抗剂 WAY-100635 阻断。这些结果表明，5-HT1A 受体激活产生的多巴胺能活性的增加可能是由 mPFC 中投射神经元活性的增加驱动的。 (c) 2005 Elsevier B.V. 和 ECNR 保留所有权利。
5-HT1A receptor agonists increase the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) and DA release in medial prefrontal cortex (mPFC). The mPFC is enriched in 5-HT1A receptors and projects to the VTA, where mesocortical dopaminergic neurons originate. We examined whether 5-HT1A receptor activation can modulate the activity of mPFC pyramidal neurons projecting to VTA. These were identified by antidromic stimulation from the VTA and were recorded extracellularly in anesthetized rats. The selective 5-HT1A agonist BAY x 3702 (10-80 mu g/kg i.v.) increased the firing rate in 14/19 neurons (283 +/- 79%) and reduced the activity of 5/19 neurons (22 +/- 11%), resulting in an overall 2.2-fold increase of the firing rate. Both effects were blocked by the selective 5-HT1A antagonist WAY-100635. These results suggest that the increase in dopaminergic activity produced by 5-HT1A receptor activation can be driven by an increase in the activity of projection neurons in mPFC. (c) 2005 Elsevier B.V. and ECNR All rights reserved.