Role of the endocrine system in the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the thymus.
Role of the endocrine system in the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the thymus.
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内分泌系统在 2,3,7,8-四氯二苯并-对-二恶英 (TCDD) 对胸腺作用中的作用。
DOI：
10.1016/0300-483x(80)90007-4
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发表时间：
1980
期刊：
影响因子：
4.5
通讯作者：
J. Moore
中科院分区：
文献类型：
--
作者：
M. J. Logten;B. N. Gupta;Ernest E. McConnell;J. Moore
通过多项实验研究了肾上腺和脑下垂体在TCDD急性毒性效应中的作用。去肾上腺或去垂体腺的大鼠单次口服2，3，7，8-四氯二苯并-对二恶英(TCDD)10或20微克/kg体重。切除肾上腺不能阻止TCDD所致的生长减慢、肝毒性作用和胸腺退缩。脑垂体腺似乎并未参与引起胸腺退化。事实上，在去垂体的大鼠中，TCDD中毒的胸腺效应甚至有所增加。生长激素治疗未能阻止胸腺退化或TCDD对肝脏的影响。
Several experiments were conducted to study the involvement of the adrenal and the pituitary gland in the acute toxic effects of TCDD. Adrenalectomized or hypophysectomized rats were treated with a single oral dose of 10 or 20 microgram of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)/kg body weight. The reduced growth rate, the hepatotoxic effects and thymic involution induced by TCDD were not prevented by the adrenalectomy. The pituitary gland did not appear to be involved in causing thymic involution. In fact, the thymic effects of TCDD intoxication were even somewhat increased in hypophysectomized rats. Treatment with growth hormone failed to prevent thymic involution or the influence of TCDD on the liver.