Enhanced expression of fractalkine in HIV-1 associated dementia
Enhanced expression of fractalkine in HIV-1 associated dementia
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DOI：
10.1016/s0165-5728(01)00262-4
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发表时间：
2001-04-02
影响因子：
3.3
通讯作者：
Nottet, HSLM
中科院分区：
文献类型：
--
作者：
Pereira, CF;Middel, J;Nottet, HSLM
CX3C趋化因子fractalkine在大脑炎症过程中被发现上调。在这项研究中，我们试图评估fractalkine在hiv -1相关痴呆中的作用。Fractalkine在患有HAD的艾滋病患者的大脑中表达上调。Fractalkine主要在星形胶质细胞中检测到免疫反应性。此外，在星形胶质细胞和HIV感染的巨噬细胞共培养中，fractalkine的表达被发现上调。这种上调依赖于细胞间的接触。我们认为星形胶质细胞和感染hiv的巨噬细胞相互作用过程中产生的fractalkine通过调节脑实质中单核细胞的运输在HAD中发挥作用。(C) 2001 Elsevier Science B.V.版权所有
The CX3C chemokine fractalkine was found to be up-regulated in the brain during inflammatory processes. In this study, we tried to assess the role of fractalkine in HIV-1-associated dementia. Fractalkine expression is up-regulated in the brains of AIDS patients with HAD. Fractalkine immunoreactivity was mainly detected in astrocytes. in addition, fractalkine expression was found to be up-regulated in cocultures of astrocytes and HIV infected macrophages. This up-regulation was dependent on cell-cell contact. We propose that fractalkine produced during interactions between astrocytes and HIV-infected macrophages plays a role in HAD by regulating the trafficking of monocytic cells in the brain parenchyma. (C) 2001 Elsevier Science B.V. All rights reserved.