Totally Implantable Oxygen Generator (TIOG) for Hypoxia and Hypoxemia
Totally Implantable Oxygen Generator (TIOG) for Hypoxia and Hypoxemia
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DOI：
10.1109/tbme.2022.3217164
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发表时间：
2023-04-01
影响因子：
4.6
通讯作者：
Kim，Albert
中科院分区：
文献类型：
--
作者：
Islam，Sayemul;Huggins，Rebecca C.;Kim，Albert
缺氧和低氧血症是指由于呼吸衰竭、癌症等原因导致细胞氧气耗尽的情况。虽然当前的治疗带来了合理的临床结果，但其氧气输送的系统性可能会因显着的脱落和副作用而受到损害。本文提出了一种完全植入式氧气发生器（TIOG），用于局部、高度可控、实时和有针对性的氧气输送。方法TIOG 系统是一个超低功耗植入式无线平台，采用现成组件构建。 TIOG 可以远程操作，以通过精确控制的电信号（即电流水平、频率和占空比）实现基于电解的定制氧气输送。结果体外实验表明，TIOG 可以通过脉冲电流（800 µA、600 µs 脉冲或 10 ms 周期的 6% 占空比）以 9.27 ± 1.9 µmol/L/min 的速率输送氧气。该系统还可以在安全准则（5 mg/L）下抑制氯的产生。 TIOG 在 433 MHz ISM 频段运行，可在最远 600 厘米的距离内进行无线控制，且误码率 (BER) 和误包率 (PER) 均为 0%。电池一次充电可使系统运行长达 3.3 小时，并且可以通过无线充电实现长期运行。结论 TIOG 系统的使用寿命使得动态氧疗的时间比目前的实践更长。
Hypoxia and hypoxemia are the conditions when oxygen is depleted from the cell due to, for example, respiratory failure, cancer, etc. While the current therapy brought reasonable clinical outcomes, its systematic nature of oxygen delivery can be compromised by a significant dropout and side effects. This paper presents a totally implantable oxygen generator (TIOG) for localized, highly controllable, real-time, and targeted oxygen delivery.MethodsThe TIOG system, an ultra-low power implantable wireless platform, is built using off-the-shelf components. The TIOG can be remotely operated to enable a tailored oxygen delivery based on electrolysis with a precisely controlled electrical signal (i.e., current level, frequency, and duty cycle).ResultsThe in vitro experiments demonstrate that the TIOG could deliver oxygen with a rate of 9.27 ± 1.9 µmol/L/min with the pulsed electrical current (800 µA, 600 µs pulse or 6% duty cycle with 10 ms period). The system could also suppress chlorine generation under the safety guideline (5 mg/L). Operating at 433 MHz ISM band, the TIOG could be wirelessly controlled from up to 600 cm distance with a 0%-bit error rate (BER) and 0%-packet error rate (PER). A single charge of the battery could operate the system for up to 3.3 hr, which can be wirelessly recharged for long-term operation.ConclusionThe longevity of the TIOG system enables ambulatory oxygen therapy in a much longer-term than current practice.