Arginine-Stimulated Hyperglucagonemia in Diabetic Pima Indians
Arginine-Stimulated Hyperglucagonemia in Diabetic Pima Indians
复制标题
糖尿病皮马印第安人中精氨酸刺激的高胰高血糖素血症
作者：
S. Aronoff;P. Bennett;N. Rushforth;M. Miller;R. Unger
27 名非糖尿病皮马印第安人、34 名非糖尿病白人和 12 名最近发病的糖尿病皮马印第安人接受精氨酸输注，以确定 (1) 非糖尿病皮马印第安人和白人对精氨酸有类似的胰高血糖素反应，以及 (2) 糖尿病皮马人对精氨酸有过度的胰高血糖素反应，正如其他种族群体所报告的那样。三组的空腹胰高血糖素水平没有显着差异。在精氨酸一氯化物输注期间（5毫克/公斤/分钟，持续40分钟），糖尿病皮马人在10分钟以及此后所有采样点的胰高血糖素水平显着高于血糖正常的皮马人。血浆胰岛素水平在输注过程中也有所增加，但值得注意的是，这两组之间从未有显着差异。非糖尿病皮马人和白种人之间任何采样点的胰高血糖素水平都没有显着差异。非糖尿病和糖尿病印度人之间胰高血糖素水平的差异与其他种族起源的糖尿病和非糖尿病受试者之间报道的差异相似。
Groups of 27 nondiabetic Pima Indians, 34 nondiabetic Caucasians, and 12 diabetic Pima Indians with recent onset of their disease received an arginine infusion to determine if (1) nondiabetic Pima Indians and Caucasians had a similar glucagon response to arginine and (2) diabetic Pimas had excessive glucagon response to arginine as reported in other racial groups. The fasting glucagon levels in the three groups were not significantly different. During arginine monochloride infusion (5 mg./kg./minute for 40 minutes) the diabetic Pimas had glucagon levels significantly higher at 10 minutes and at all sampling points thereafter than the normo-glycemic Pimas. Plasma insulin levels also increased during the infusion but, notably, never differed significantly between these two groups. There was no significant difference in the glucagon levels at any sampling point between the nondiabetic Pimas and Caucasians. The differences in glucagon levels between the nondiabetic and diabetic Indians are similar to those differences reported between diabetic and nondiabetic subjects of other racial origins.