Action spectrum of vascular specific injury using pulsed irradiation.
Action spectrum of vascular specific injury using pulsed irradiation.
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使用脉冲照射的血管特异性损伤的作用谱。
DOI：
10.1111/1523-1747.ep12696885
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Kurban,AK
中科院分区：
文献类型：
--
作者：
Tan,OT;Murray,S;Kurban,AK
已经清楚地证明，波长与发色团的三个吸收光谱峰之一相匹配的激光将选择性地损伤皮肤血管，例如，577 nm。限制该波长用于治疗良性皮肤血管肿瘤，如Portwine染色，穿透深度为577 nm，照射距离真皮表皮交界处(DEJ)约0.5 mm。本研究旨在确定是否有可能通过改变波长使其在白化猪皮中的穿透深度从0.5 mm增加到577 nm以上。这项研究的结果证实，在4J/c2下，通过将波长从577 nm改变为585 nm，穿透深度从0.5 mm增加到1.2 mm，同时保持与先前描述的577 nm照射后相同的血管选择性。尽管585 nm和577 nm的氧合血红蛋白吸收峰之间的波长不匹配，但还是发生了这种情况。与585 nm的照射不同，与乐观的预测相反，590 nm的激光没有穿透到585 nm的深度。4J/cm2激光照射不仅使585 nm处的穿透率从1.2 mm降低到590 nm处的0.8 mm，而且白化猪皮肤对590 nm照射的血管选择性也降低。
It has been clearly demonstrated that cutaneous blood vessels will be selectively damaged by a laser whose wavelength matches one of the three absorption spectral peaks of the chromophore, oxyhemoglobin, for example, 577 nm. A restriction in the application of this wavelength for the treatment of benign cutaneous vascular tumors, such as portwine stains, has been the penetration depth of 577 nm irradiation of approximately 0.5 mm from the dermal epidermal junction (DEJ). This study was undertaken to establish whether it was possible to increase the penetration depth from 0.5 mm by changing the wavelength to beyond 577 nm in albino pig skin. Results from this study confirm that penetration depth increases from 0.5 to 1.2 mm by changing the wavelength from 577 to 585 nm at 4 J/c2, while maintaining the same degree of vascular selectivity as that previously described after 577 nm irradiation. This occurred in spite of a mismatch in the wavelength between 585 nm and the oxyhemoglobin absorption peak of 577 nm. Unlike 585 nm irradiation and in contrast with cheoretical predictions, 590 nm laser light did not penetrate as deeply as 585 nm. Not only was there a reduction in the penetration of the laser beam from 1.2 mm at 585 nm to 0.8 mm at 590 nm, at 4 J/cm2, but there was also a decrease in vascular selectivity in albino pig skin exposed to 590 nm irradiation.