Muscle pain sensitivity after glutamate injection is not modified by systemic administration of monosodium glutamate.
Muscle pain sensitivity after glutamate injection is not modified by systemic administration of monosodium glutamate.
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DOI：
10.1186/s10194-015-0546-0
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Svensson P
中科院分区：
文献类型：
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作者：
Shimada A;Castrillon E;Baad-Hansen L;Ghafouri B;Gerdle B;Ernberg M;Cairns B;Svensson P
谷氨酸钠（MSG）通常被认为与头痛和颅面疼痛有关，如颞下颌关节紊乱病。这项随机、双盲、安慰剂对照的研究旨在研究在实验诱导肌肉疼痛之前和之后，摄入味精如何影响肌肉疼痛敏感性。16名健康成人受试者参加了2个阶段，两个阶段之间至少间隔1周。在每个疗程中，分别向咬肌和颞肌注射两次谷氨酸盐（Glu，0.5 M，0.2 ml）和两次盐水（0.9%，0.2 ml），每次注射之间间隔15 min。在Glu注射的对侧进行盐水注射，并以随机顺序进行。参与者在肌肉注射前30分钟喝了400 mL与MSG（150 mg/kg）或NaCl（24 mg/kg，安慰剂）混合的苏打水。在摄入苏打水之前（基线）和30分钟后，以及肌肉注射后5分钟和10分钟以及疗程结束时，评估压痛阈值（PPT）、自主神经参数和疼痛强度。在摄入苏打水之前和之后30、45、60和75分钟收集全唾液样本。味精管理导致唾液中的谷氨酸水平显着高于管理的NaCl，并与收缩压显着增加。注射Glu比注射NaCl明显更痛。然而，味精的摄入并没有改变谷氨酸引起的疼痛的强度。谷氨酸注射也显著增加收缩压和舒张压，但没有味精摄入的额外影响。谷氨酸注射到咬肌显着降低PPT。然而，注射前的味精摄入并没有显着改变这种效果。有趣的是，PPT显着增加后，味精摄入和肌肉注射谷氨酸在颌骨肌肉的肌肉。这项研究的主要发现是，全身摄入大量的味精不会影响注射谷氨酸的咬肌和颞肌的疼痛强度或压痛敏感性。
Monosodium glutamate (MSG) is often thought to be associated with headache and craniofacial pains like temporomandibular disorders. This randomized, double-blinded, placebo-controlled study was performed to investigate how ingestion of MSG affects muscle pain sensitivity before and after experimentally induced muscle pain. Sixteen healthy adult subjects participated in 2 sessions with at least 1-week interval between sessions. In each session, two injections of glutamate (Glu, 0.5 M, 0.2 ml) and two injections of saline (0.9 %, 0.2 ml) into the masseter and temporalis muscles, respectively, were undertaken, with a 15 min interval between each injection. Injections of saline were made contralateral to Glu injections and done in a randomized order. Participants drank 400 mL of soda mixed with either MSG (150 mg/kg) or NaCl (24 mg/kg, placebo) 30 min before the intramuscular injections. Pressure pain thresholds (PPT), autonomic parameters and pain intensity were assessed prior to (baseline) and 30 min after ingestion of soda, as well as 5 min and 10 min after the intramuscular injections and at the end of the session. Whole saliva samples were collected prior to and 30, 45, 60, and 75 min after the ingestion of soda. MSG administration resulted in a significantly higher Glu level in saliva than administration of NaCl and was associated with a significant increase in systolic blood pressure. Injections of Glu were significantly more painful than injections of NaCl. However, ingestion of MSG did not change the intensity of Glu-evoked pain. Glu injections also significantly increased systolic and diastolic blood pressure, but without an additional effect of MSG ingestion. Glu injections into the masseter muscle significantly reduced the PPT. However, pre-injection MSG ingestion did not significantly alter this effect. Interestingly, PPT was significantly increased in the trapezius after MSG ingestion and intramuscular injection of Glu in the jaw muscles. The main finding in this study was that systemic intake of a substantial amount of MSG does not influence either pain intensity or pressure pain sensitivity in the masseter and temporalis muscles into which Glu injections were made.