Patrilocal cell-cell interactions: Sevenless captures its bride
Patrilocal cell-cell interactions: Sevenless captures its bride
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DOI：
10.1016/0962-8924(93)90165-w
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发表时间：
1993-01-01
影响因子：
19
通讯作者：
Kramer, Helmut
中科院分区：
文献类型：
--
作者：
Kramer, Helmut
果蝇复眼中R7神经元的发育需要R8感光细胞和双能R7前体细胞之间的诱导相互作用。两种跨膜蛋白介导这种诱导：sevenless（sev），一种在R7前体细胞顶端表面表达的受体酪氨酸激酶，及其配体，在R8神经元顶端膜上的sevenless蛋白（boss）的新娘。boss蛋白具有较大的胞外结构域和7个跨膜片段，是受体酪氨酸激酶的一种不寻常的配体，其在与sev相互作用后内化到R7细胞中特别有趣。
Development of the R7 neuron in the compound eye of Drosophila requires an inductive interaction between the R8 photoreceptor cell and the bipotential R7 precursor cell. Two transmembrane proteins mediate this induction: sevenless (sev), a receptor tyrosine kinase expressed on the apical surface of the R7 precursor cell, and its ligand, the bride of sevenless protein (boss) on the apical membrane of the R8 neuron. The boss protein, with its large extracellular domain and seven transmembrane segments, is an unusual ligand for a receptor tyrosine kinase, and its internalization into the R7 cell following interaction with sev is particularly intriguing.