The postnatal development of myoepithelial cells in the rat submandibular gland
The postnatal development of myoepithelial cells in the rat submandibular gland
复制标题
大鼠颌下腺肌上皮细胞的出生后发育
DOI：
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复制
发表时间：
1972
期刊：
影响因子：
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通讯作者：
F. Archer
中科院分区：
文献类型：
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作者：
S. Line;F. Archer
SummaryFluorescein-labeled antibody against human uterine actomyosin was used as a histochemical stain to identify and localize myoepithelial cells during the early stages of differentiation of the rat submandibular gland. Smooth muscle and myoepithelium of the rat in tissue sections reacted specifically with the antiserum, indicating close antigenic relationship between smooth muscle proteins of these two species. At birth the rat submandibular gland has neither acini nor myoepithelial cells, but by 24 hours after birth a few positively fluorescent cells in the characteristic position of myoepithelium were identified around the terminal tubules. By 1 week they had formed an extensive network around the terminal tubular structures, and from the first until the fifth week continued gradually to increase in number, reaching approximately the adult number and distribution.Alkaline phosphatase is not present in detectable amounts in myoepithelial cells until the third postnatal day. From then until the fifth week alkaline phosphatase localization demonstrates a developmental pattern of myoepithelial cells similar to that shown by immunofluorescence methods.The appearance of these cells in the early postnatal period suggests that they play a functional role in the movement of secretions in the immature gland. Although the origin of myoepithelial cells remains unknown, differentiation from uncommitted cells within the terminal tubule, or migration of cells from a position external to the basement membrane are suggested as possible modes of development.
