POTASSIUM CURRENTS IN DROSOPHILA - DIFFERENT COMPONENTS AFFECTED BY MUTATIONS OF 2 GENES
POTASSIUM CURRENTS IN DROSOPHILA - DIFFERENT COMPONENTS AFFECTED BY MUTATIONS OF 2 GENES
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DOI：
10.1126/science.6302847
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
LIU, AX
中科院分区：
文献类型：
--
作者：
WU, CF;GANETZKY, B;LIU, AX
果蝇行为突变体Eag和Sh以及双突变体Eag Sh的电生理分析表明，这两个基因的产物都参与了神经和肌肉膜中K电流的控制。在电压钳位幼虫肌纤维，SH影响的瞬态A电流，而EAG减少延迟整流，并在较小程度上，A电流。
Electrophysiological analysis of the Drosophila behavioral mutants Eag and Sh and the double mutant Eag Sh indicates that the products of both genes take part in the control of K currents in the membranes of both nerve and muscle. In voltage-clamped larval muscle fibers, Sh affects the transient A current, whereas Eag reduces the delayed rectification and, to a lesser extent, the A current.