ENCEPHALODUROARTERIOSYNANGIOSIS (EDAS) FOR THE TREATMENT OF CHILDHOOD MOYAMOYA DISEASE
ENCEPHALODUROARTERIOSYNANGIOSIS (EDAS) FOR THE TREATMENT OF CHILDHOOD MOYAMOYA DISEASE
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DOI：
10.1016/0887-8994(94)90023-x
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发表时间：
1994-05-01
影响因子：
3.8
通讯作者：
OGORMAN, AM
中科院分区：
文献类型：
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作者：
ROSS, IB;SHEVELL, MI;OGORMAN, AM
Moyamoya病的定义是血管造影显示大脑底部前循环血管狭窄或闭塞，并伴随着侧支供血的发展。未经治疗，这种疾病通常是临床进展，导致严重的神经系统后遗症。脑硬脊膜动脉联合血管形成（EDAS）涉及将一段头皮动脉转位到大脑表面，是一种旨在改善侧支血流的外科治疗。6名儿童接受了8次EDAS手术，术后随访6个月至9年。无患者发生神经系统状态进一步恶化。术后血管造影显示，研究的6例EDAS中有3例从供体头皮动脉进行了脑血管重建。EDAS后未实现血运重建的2例患者显示其疾病的血管造影消退。这些数据表明EDAS是治疗儿童烟雾病的安全方法。考虑到后遗症的潜在严重性，建议对所有患有这种疾病的儿童进行早期手术干预。
Moyamoya disease is defined by the angiographic demonstration of stenosis or occlusion of the vessels of the anterior circulation at the base of the brain and the concomitant development of collateral blood supply. Untreated, the disease is often clinically progressive, resulting in significant neurologic sequelae. Encephaloduroarteriosynangiosis (EDAS), which involves the transposition of a segment of a scalp artery onto the surface of the brain, is a surgical treatment aimed at improving collateral blood flow. Six children underwent 8 EDAS procedures and were followed from 6 months to 9 years after surgery. No patient experienced further deterioration in neurologic status. Postoperative angiography demonstrated cerebral revascularization from the donor scalp artery on 3 of the 6 EDASs that were studied. The 2 patients who did not revascularize after EDAS demonstrated angiographic regression of their disease. The data suggest that EDAS is a safe procedure for the treatment of childhood moyamoya disease. Given the potential severity of the sequelae, early operative intervention is recommended in all children with this disease.