TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.
TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.
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DOI：
10.1186/1471-2407-7-175
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发表时间：
2007-09-11
期刊：
影响因子：
3.8
通讯作者：
Hunter DJ
中科院分区：
文献类型：
--
作者：
Cox DG;Penney K;Guo Q;Hankinson SE;Hunter DJ
转化生长因子β1(TGFB1)与转化生长因子β受体1和2形成信号复合体，既是肿瘤抑制因子，又是肿瘤促进剂。TGFB1和TGFBR1中的一个微卫星的单核苷酸多态与乳腺癌的风险相关，但结果相互矛盾。我们在护士健康研究队列中检测了TGFB1基因启动子区域以及TGFBR1*6A微卫星的多态。未发现TGFB1的L10P多态与TGFBR1微卫星之间的总体关联。然而，我们观察到TGFB1的-509C/T多态之间呈负相关(p-趋势=0.04)，这在雌激素受体阳性的乳腺癌患者中更为明显。在高加索女性中，TGFB1启动子区域的多态不太可能与乳腺癌风险的大幅增加有关。
Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results. We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort. No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse association between the -509 C/T polymorphism of TGFB1 (p-trend = 0.04), which was stronger and more significant among women with estrogen receptor positive breast cancer. Polymorphisms in the promoter region of TGFB1 are not likely to be associated with large increases in breast cancer risk overall among Caucasian women.
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影响因子：
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作者：
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