Changes in urinary titin fragment in response to different types of dynamic eccentric exercises.
Changes in urinary titin fragment in response to different types of dynamic eccentric exercises.
复制标题
不同类型的动态离心运动引起的尿肌蛋白片段的变化。
DOI：
10.1055/a-1273-8082
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发表时间：
2021
期刊：
影响因子：
2.5
通讯作者：
W. Ziolkowski.
中科院分区：
文献类型：
--
作者：
M. Lee;K. Goral;D.J. Flis;W. Skrobot;K. Cieminski;R.A. Olek;T. Akimoto;W. Ziolkowski.
肌联蛋白片段的尿水平被认为是临床病例中肌肉损伤的非侵入性和敏感的生物标志物。然而，很少有证据表明，尿肌联蛋白片段的变化，在运动引起的肌肉损伤。在这项研究中，我们的目的是调查尿肌联蛋白片段是否反映了两个下肢离心运动引起的肌肉损伤的程度。在这项研究中，健康的年轻男性受试者进行了下降跳跃（n=9）和离心功量计运动（n=9）。在运动前后的不同时间点采集血液和尿液样本。虽然感觉到的肌肉酸痛评估坐立任务后24小时和48小时的下降跳跃和偏心测力计运动组增加，压力疼痛阈值没有改变。离心运动后尿肌联蛋白片段、血浆肌溶蛋白3片段、肌酸激酶（CK）和肌红蛋白（Mb）的变化有所增加，但无统计学意义。同时，我们发现，滴跳和离心功量计运动时尿titin片段水平的变化与血浆CK和Mb水平的变化相关。这些结果提供了证据表明，尿肌联蛋白片段水平是一种非侵入性的生物标志物，反映了离心运动引起的肌肉损伤的程度。
The urinary level of the titin fragment has been considered a non-invasive and sensitive biomarker for muscle damage in clinical cases. However, there is little evidence regarding changes in the urinary titin fragment in response to exercise-induced muscle damage. In this study, we aimed to investigate whether the urinary titin fragment reflects the magnitude of muscle damage induced by two lower-limb eccentric exercises. In this study, healthy young male subjects performed drop jump (n=9) and eccentric ergometer exercise (n=9). Blood and urine samples were collected at various time points before and after the exercises. Although perceived muscle soreness assessed by sit-to-stand tasks was increased at 24 h and 48 h after both drop jump and the eccentric ergometer exercise groups, the pressure pain threshold was not changed. Changes of the urinary titin fragment, plasma myomesin 3 fragments, creatine kinase (CK), and myoglobin (Mb) after the eccentric exercises were increased but not statistically significant. Meanwhile, we found that the changes in the urinary titin fragment levels in response to both drop jump and the eccentric ergometer exercise were correlated with those of plasma CK and Mb levels. These results provide evidence that the urinary titin fragment level is a non-invasive biomarker reflecting the magnitude of eccentric exercise-induced muscle damage.