A ROLE FOR THE NEURAL CELL-ADHESION MOLECULE, NCAM, IN MYOBLAST INTERACTION DURING MYOGENESIS
A ROLE FOR THE NEURAL CELL-ADHESION MOLECULE, NCAM, IN MYOBLAST INTERACTION DURING MYOGENESIS
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DOI：
10.1016/0012-1606(90)90185-l
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发表时间：
1990-03-01
影响因子：
2.7
通讯作者：
MYERS, L
中科院分区：
文献类型：
--
作者：
KNUDSEN, KA;MCELWEE, SA;MYERS, L
Ca2+独立的神经细胞粘附分子NCAM由神经和肌肉细胞表达，并已被证明介导神经-神经和神经-肌肉细胞相互作用。NCAM在肌肉细胞相互作用中的作用已被提出，但尚未得到证实。在这里，我们报道了在体外发育过程中NCAM在鸡胚肌细胞中表达的证据，并与Ca2+依赖性粘附分子一起在多核细胞形成过程中介导成肌细胞相互作用。
The Ca2+-independent neural cell adhesion molecule, NCAM, is expressed by both nerve and muscle cells and has been shown to mediate both nerve-nerve and nerve-muscle cell interaction. A role for NCAM in muscle-muscle cell interaction has been proposed but not demonstrated. Here we report evidence that NCAM is expressed by embryonic chick muscle cells during in vitro development and functions together with Ca2+-dependent adhesion molecules in mediating myoblast interaction during the formation of multinucleate cells.