Western blot analysis of anti-Escherichia coli serum immunoglobulins in women susceptible to recurrent urinary tract infections.
Western blot analysis of anti-Escherichia coli serum immunoglobulins in women susceptible to recurrent urinary tract infections.
复制标题
对易患复发性尿路感染的女性进行抗大肠杆菌血清免疫球蛋白的蛋白质印迹分析。
DOI：
10.1093/infdis/172.6.1612
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Uehling,DT
中科院分区：
文献类型：
--
作者：
Hopkins,WJ;Xing,Y;Dahmer,LA;Balish,E;Uehling,DT
The basis for increased susceptibility of some women to recurrent urinary tract infections (UTIs) is not clear; increased susceptibility may be due to host factors that promote increased colonization of the vaginal and bladder mucosa with uropathogens or to decreased immune responses to uropathogens. Anti-Escherichia coliantibody specificities in sera from UTI patients and controls were comprehensively assessed to determine whether UTI-susceptible and -nonsusceptible women differed in their capacities to make antibodies to individualE. coliantigens. Sera were analyzed by one-dimensional Western blots using antigens prepared from uropathogenicE. coli. The results showed that sera from subjects without a history of recurrent UTIs contained IgG antibodies to specificE. coliantigens more often than did sera from UTI-susceptible patients. These data suggest that hyporesponsiveness to specificE. coliantigens may be linked to increased UTI susceptibility in some women.
