Effect of phosphate group addition on the properties of denture base resins.
Effect of phosphate group addition on the properties of denture base resins.
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DOI：
10.1016/s0022-3913(08)60210-3
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发表时间：
2008-10
影响因子：
4.6
通讯作者：
Dentino, Andrew R.
中科院分区：
文献类型：
--
作者：
Puri, Gaurav;Berzins, David W.;Dhuru, Virendra B.;Raj, Periathamby A.;Rambhia, Sameer K.;Dhir, Gunjan;Dentino, Andrew R.
丙烯酸树脂易于被微生物粘附，尤其是被白色念珠菌粘附。表面带电树脂改变义齿树脂和念珠菌菌丝之间的离子相互作用，这些树脂正在开发作为一种手段，以减少义齿表面上的微生物定植。本研究的目的是探讨含磷酸盐的聚甲基丙烯酸甲酯树脂作为义齿材料的适用性的物理和机械性能。使用具有交联剂（Lucitone 199）的PMMA作为对照，产生含有各种水平的磷酸盐的具有和不具有交联剂的4个实验组。性能检查的冲击强度，断裂韧性，润湿性（接触角），和树脂粘接义齿的能力。在悬臂梁构型中测试冲击强度（n=16），并且使用单边缺口弯曲测试测量断裂韧性（n=13）。通过计算水在材料表面上的接触角来确定润湿性（n=12），而ISO 1567用于粘合能力（n=12）。通过单因素和双因素ANOVA（α=.05）分析数据。随着磷酸盐浓度的增加，观察到亲水性增加的趋势，如由较低的接触角所指示的。至于其他性能，与对照丙烯酸树脂相比，没有发现显着差异。在丙烯酸义齿树脂中没有发现由于添加含磷酸盐单体而产生的不良物理效应。需要进行额外的机械和物理性能、生物相容性和临床疗效研究，以确认这些新型树脂的体内抗念珠菌活性。
Acrylic resins are prone to microbial adherence, especially by Candida albicans. Surface-charged resins alter the ionic interaction between the denture resin and Candida hyphae, and these resins are being developed as a means to reduce microbial colonization on the denture surface. The purpose of this study was to investigate the physical and mechanical properties of phosphate-containing polymethyl methacrylate resins for their suitability as a denture material. Using PMMA with cross-linker (Lucitone 199) as a control, 4 experimental groups containing various levels of phosphate with and without cross-linker were generated. The properties examined were impact strength, fracture toughness, wettability (contact angle), and resin bonding ability to denture teeth. Impact strength was tested in the Izod configuration (n=16), and fracture toughness (n=13) was measured using the single-edge notched bend test. Wettability was determined by calculating the contact angle of water on the material surface (n=12), while ISO 1567 was used for bonding ability (n=12). The data were analyzed by 1- and 2-way ANOVA (α=.05). A trend of increased hydrophilicity, as indicated by lower contact angle, was observed with increased concentrations of phosphate. With regard to the other properties, no significant differences were found when compared with the control acrylic resin. No adverse physical effect due to the addition of a phosphate-containing monomer was found in the acrylic denture resins. Additional mechanical and physical properties, biocompatibility, and clinical efficacy studies are needed to confirm the in vivo anti-Candida activity of these novel resins.