A competing risks analysis of bloodstream infection after stem-cell transplantation using subdistribution hazards and cause-specific hazards
A competing risks analysis of bloodstream infection after stem-cell transplantation using subdistribution hazards and cause-specific hazards
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DOI：
10.1002/sim.3006
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发表时间：
2007-12-30
影响因子：
2
通讯作者：
Schumacher, Martin
中科院分区：
文献类型：
--
作者：
Beyersmann, Jan;Dettenkofer, Markus;Schumacher, Martin
外周血干细胞移植后，接受严重血液疾病治疗的患者进入危重阶段(中性粒细胞减少症)。分析中性粒细胞减少期间的血流感染必须考虑相互竞争的风险。对所有特定原因的危险进行单独的COX分析是标准的选择方法，但当协变量对累积关联函数(CIF)的整体影响值得关注时，就很难解释了。CIF次要分布的比例次要分布风险模型正在将其本身确立为一种便于解释的替代方案。我们应用了这两种方法，并讨论了它们的相对优点。版权所有2007 John Wiley&Sons，Ltd.
After peripheral blood stem-cell transplantation, patients treated for severe haematologic diseases enter a critical phase (neutropenia). Analysis of bloodstream infection during neutropenia has to account for competing risks. Separate Cox analyses of all cause-specific hazards are the standard technique of choice, but are hard to interpret when the overall effects of covariates on the cumulative incidence function (CIF) are of interest. Proportional subdistribution hazards modelling of the subdistribution of the CIF is establishing itself as an interpretation-friendly alternative. We apply both methods and discuss their relative merits. Copyright 2007 John Wiley & Sons, Ltd.