Iminophosphorane-organogold(III) complexes induce cell death through mitochondrial ROS production.
Iminophosphorane-organogold(III) complexes induce cell death through mitochondrial ROS production.
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DOI：
10.1016/j.jinorgbio.2011.06.004
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发表时间：
2011-10
影响因子：
3.9
通讯作者：
Marzo, Isabel
中科院分区：
文献类型：
--
作者：
Vela, Laura;Contel, Maria;Palomera, Luis;Azaceta, Gemma;Marzo, Isabel
Gold compounds are being investigated as potential antitumor drugs. Some gold(III) derivatives have shown to induce cell death in solid tumors but their mechanism of action differs from that of cisplatin, since most of these compounds do not bind to DNA. We have explored cellular events triggered by three different iminophosphorane-organo gold(III) compounds in leukemia cells (a neutral compound with two chloride ligands [Au{κ2-C,N-C6H4(PPh2=N(C6H5)-2}Cl2] 1, and two cationic compounds with either a dithiocarbamate ligand [Au{κ2-C,N-C6H4(PPh2=N(C6H5)-2}(S2CN-Me2)]PF6 2, or a water-soluble phosphine and a chloride ligand [Au{κ2-C,N-C6H4(PPh2=N(C6H5)-2}(P{Cp(m-C6H4-SO3Na)2}3) Cl]PF6 3). All three compounds showed higher toxicity against leukemia cells when compared to normal T-lymphocytes. Compounds 1 and 2 induced both necrosis and apoptosis, while 3 was mainly apoptotic. Necrotic cell death induced by 1 and 2 was Bax/Bak- and caspase-independent, while apoptosis induced by 3 was Bax/Bak-dependent. Reactive oxygen species (ROS) production at the mitochondrial level was a critical step in the antitumor effect of these compounds.
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DOI：
10.1155/2008/864653
发表时间：
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期刊：
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影响因子：
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