Investigation of the riddle of sulfathiazole polymorphism
Investigation of the riddle of sulfathiazole polymorphism
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DOI：
10.1016/j.ijpharm.2011.05.004
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发表时间：
2011-07-29
影响因子：
5.8
通讯作者：
Dann, Sandy E.
中科院分区：
文献类型：
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作者：
Abu Bakar, Mohd R.;Nagy, Zoltan K.;Dann, Sandy E.
自1939年发现磺胺噻唑作为抗菌药物以来，对其不同形态的筛选工作已经进行并发表，这是药物开发的重要组成部分。这些工作结果导致了产生特定多晶型的各种方法的可用性。然而，通过这些方法，人们不能保证获得预期的纯多晶，因为大多数方法不能清楚和充分地描述结晶条件，如冷却速率和初始溶质浓度。本文综述了磺胺噻唑所有已知多晶型化合物的生成方法，并介绍了生成某些多晶型化合物的选择方法，这些方法使用过程分析技术工具（即聚焦光束反射测量和衰减全反射紫外光谱）对其过程进行监测。使用各种表征方法检查所得晶体的性质，并尽可能与其他工人的晶体进行比较。(C) 2011 Elsevier B.V.版权所有
Since the discovery of sulfathiazole as an antimicrobial agent in 1939, numerous works in the screening for its different polymorphic forms, which is an essential part of drug development, have been conducted and published. These works consequently result in the availability of various methods for generating a particular polymorph. By following these methods, however, one cannot be guaranteed to obtain the intended pure polymorph because most of the methods do not clearly and adequately describe the crystallisation conditions, such as cooling rates and initial solute concentrations. In this paper, the available methods for generating all the known polymorphs of sulfathiazole are reviewed and selected methods for generating certain polymorphs, performed with their processes monitored using process analytical technology tools, i.e. focussed beam reflectance measurement and attenuated total reflectance ultraviolet spectroscopy, are presented. The properties of the obtained crystals, examined using various characterisation methods, are also presented and whenever possible, are compared with those of other workers. (C) 2011 Elsevier B.V. All rights reserved.