Severe aplastic anaemia after serial vaccinations for SARS-CoV-2, pneumococcus and seasonal influenza.
Severe aplastic anaemia after serial vaccinations for SARS-CoV-2, pneumococcus and seasonal influenza.
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DOI：
10.1002/jha2.443
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发表时间：
2022-08
期刊：
影响因子：
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通讯作者：
Babushok, Daria V
中科院分区：
文献类型：
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作者：
Wang, Xiao;Laczko, Dorottya;Caponetti, Gabriel C;Rabatin, Susan;Babushok, Daria V
我们介绍一名67岁女性，在10个月内出现进行性全血细胞减少，期间接种了严重急性呼吸综合征冠状病毒2（SARS - CoV - 2）、肺炎球菌和流感疫苗。她在接种SARS - CoV - 2信使核糖核酸（mRNA）疫苗系列约2周后出现轻度白细胞减少，在后续接种疫苗后症状逐渐加重，最终发展为重型再生障碍性贫血（SAA）。虽然已有几例疫苗相关SAA的报道，但在提交本病例时，我们的病例是首例在接种莫德纳mRNA SARS - CoV - 2疫苗后发生的，也是首例记录了在多次接种疫苗过程中SAA逐渐发展的病例。考虑到当前2019冠状病毒病疫苗接种工作的广泛开展，医生应认识到与疫苗相关的SAA。
We present a 67‐year‐old woman who developed progressive pancytopenia over 10 months, concomitant with administration of severe adult respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), pneumococcal and influenza vaccines. She developed mild leukopenia ∼2 weeks after the SARS‐CoV‐2 mRNA vaccine sequence, with progressive symptoms after subsequent vaccines, eventually developing severe aplastic anaemia (SAA). While there have been several reports of vaccine‐related SAA, at time of submission, our case is the first reported to develop after the Moderna mRNA SARS‐CoV‐2 vaccine, as well as the first to document the gradual development of SAA over the course of many vaccine exposures. Physicians should be cognizant of vaccine‐associated SAA, considering current widespread coronavirus disease 2019 vaccination efforts.