A dopamine-synthesizing cell group demonstrated in the human basal forebrain by dual labeling immunohistochemical technique of tyrosine hydroxylase and aromatic l-amino acid decarboxylase
A dopamine-synthesizing cell group demonstrated in the human basal forebrain by dual labeling immunohistochemical technique of tyrosine hydroxylase and aromatic l-amino acid decarboxylase
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通过酪氨酸羟化酶和芳香族 L-氨基酸脱羧酶的双标记免疫组织化学技术在人基底前脑中证实了多巴胺合成细胞群
DOI：
10.1016/s0304-3940(98)00103-7
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发表时间：
1998
影响因子：
2.5
通讯作者：
R. Arai
中科院分区：
文献类型：
--
作者：
K. Ikemoto;I. Nagatsu;K. Kitahama;A. Jouvet;A. Nishimura;K. Nishi;T. Maeda;R. Arai
已知人基底前脑含有许多对酪氨酸羟化酶（TH;第一种多巴胺合成酶）免疫反应（ir）的神经元。我们研究了这些神经元是否可能含有芳香族L-氨基酸脱羧酶（AADC;多巴胺合成酶的第二步）的双标记免疫组织化学和共聚焦激光扫描显微镜。TH和AADC双标神经元分布于嗅前核、嗅结节和嗅前核腹侧缘。对猕猴基底前脑的检查也得到了基本相同的结果。这些神经元似乎构成了一个独立的多巴胺能细胞群在灵长类动物基底前脑。
The human basal forebrain has been known to contain many neurons immunoreactive (ir) to tyrosine hydroxylase (TH; the first dopamine-synthesizing enzyme). We examined whether these neurons might contain aromatic l-amino acid decarboxylase (AADC; the second step dopamine-synthesizing enzyme) by dual labeling immunohistochemistry and confocal laser-scanning microscopy. Neurons dually-labeled for TH and AADC were found in the anterior olfactory nucleus, olfactory tubercle and the ventral margin of the rostral nucleus accumbens. The examination in the basal forebrain of the macaque monkey also gave substantially the same results. These neurons appear to constitute an independent dopaminergic cell group in the primate basal forebrain.