Predicting complications of pregnancy with first-trimester maternal serum free-βhCG, PAPP-A and inhibin-A
Predicting complications of pregnancy with first-trimester maternal serum free-βhCG, PAPP-A and inhibin-A
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DOI：
10.1002/pd.735
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发表时间：
2003-12-15
影响因子：
3
通讯作者：
Novak-Antolic, Z
中科院分区：
文献类型：
--
作者：
Tul, N;Pusenjak, S;Novak-Antolic, Z
目的探讨在孕早期筛查21三体（T21）时，孕妇血清中fbetahCG、PAPP-A和BABIN-A水平及胎儿颈部透明带（NT）厚度是否可作为不良妊娠结局高危孕妇的检测指标。有妊娠并发症的妇女被分为五个亚组：小于胎龄儿（SGA），大于胎龄儿（LGA），妊娠期糖尿病（GDM），高血压疾病，早产;正常妊娠的妇女代表对照组。测定NT、母血fbetaCG、PAPP-A和HbA 1c-A。用Mann-Whitney检验比较妊娠并发症亚组与对照组的fbetahCG、PAPP-A、BAP-A和NT。结果SGA组PAPP-A值显著低于LGA组（n = 51，0.76 MoM; p = 0.002），LGA组PAPP-A值显著高于SGA组（n = 120，1.12 MoM; p = 0.036）。在GDM妇女（n = 27）中，fbetahCG、PAPP-A和BABIN-A均无显著性低于对照组，而在高血压妇女（n = 56）中，两组间无显著性差异。
Objective To find whether fbetahCG, PAPP-A and inhibin-A levels in maternal serum or fetal nuchal translucency (NT) thickness at the first-trimester screening for trisomy 21 (T21) might detect women at high risk for adverse pregnancy outcomes.Methods A retrospective analysis of 1136 women with singleton pregnancy between 10 and 14 weeks. Women with pregnancy complications were allotted to five subgroups: small for gestational age (SGA), large for gestational age (LGA), gestational diabetes (GDM), hypertensive disorders, preterm delivery; women with normal pregnancy represented the control group. NT, maternal serum fbetaCG, PAPP-A and inhibin-A were measured. Mann-Whitney test was used for the comparison of fbetahCG, PAPP-A, inhibin-A and NT between a subgroup of a certain pregnancy complication and the control group. Multivariate logistic regression models were built to explore the relationship among different variables and the occurrence of pregnancy complications.Results PAPP-A values were significantly lower in women who delivered SGA babies (n = 51, 0.76 MoM; p = 0.002) and significantly higher in women who delivered LGA babies (n = 120, 1.12 MoM; p = 0.036). In women with GDM (n = 27), fbetahCG, PAPP-A and inhibin-A were insignificantly lower than in controls, whereas in women with hypertensive disorders (n = 56) no significant differences between the groups were found. In women with a preterm delivery (