Synthesis of a mimic for the heterogeneous surface of core 2 sialoglycan-linked glycoprotein
Synthesis of a mimic for the heterogeneous surface of core 2 sialoglycan-linked glycoprotein
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DOI：
10.1021/ol048827b
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发表时间：
2004-09-02
期刊：
影响因子：
5.2
通讯作者：
Nakahara, Y
中科院分区：
文献类型：
--
作者：
Takano, Y;Hojo, H;Nakahara, Y
合成了一种携带两种不同糖型的核心2唾液五糖的o糖基化肽，作为粘蛋白糖蛋白异质表面的模型。固相合成和随后的酶催化唾液化得到两个片段，它们通过选择性硫酯活化偶联产生标题化合物。
An O-glycosylated peptide carrying two core 2 sialopentasaccharides of different glycoform was synthesized as a model of the heterogeneous surface of mucin glycoprotein. Solid-phase synthesis and the subsequent enzymatic sialylation gave two segments, which were coupled by selective thioester activation to produce the title compound.