Longitudinal Growth Curves of Brain Function Underlying Inhibitory Control through Adolescence
Longitudinal Growth Curves of Brain Function Underlying Inhibitory Control through Adolescence
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DOI：
10.1523/jneurosci.1741-13.2013
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发表时间：
2013-11-13
影响因子：
5.3
通讯作者：
Luna, Beatriz
中科院分区：
文献类型：
--
作者：
Ordaz, Sarah J.;Foran, William;Luna, Beatriz
神经影像学研究表明，抑制控制的发展改善主要是由前额叶执行功能的变化支持的。然而，研究是矛盾的，关于如何激活前额叶区域随着年龄的变化，他们还没有分析纵向数据使用生长曲线模型，它允许表征动态过程的发展变化，个体差异的增长轨迹，和变量，预测任何个体间的变化轨迹。在这项研究中，我们提出了从纵向fMRI数据收集超过302次访问（年龄9至26岁）从123名人类参与者建模的生长曲线。已知支持运动反应控制、执行控制和错误处理（即，抑制控制方面）进行了研究。研究结果揭示了不同的发展轨迹，每个电路内的区域，并表明，一个层次模式的成熟的大脑激活支持逐渐出现的成人样抑制控制。运动反应控制区激活的平均增长曲线显示，随着年龄的增长没有变化，虽然个体间的变异性随着发展而下降，表明与成熟的等同性。某些执行控制区域的激活随着年龄的增长而下降，直到青春期，并且在整个发育过程中变化是稳定的。背侧前扣带皮层的错误处理激活持续增加到成年期，在整个发育过程中没有显著的个体间差异，并且与任务表现唯一相关。这些研究结果提供的证据表明，错误处理能力的持续成熟支持抑制控制在青春期的长期发展，而运动反应控制区域提供了早期成熟的基础能力，并建议一些执行控制区域可能会支持不成熟的网络错误处理继续成熟。
Neuroimaging studies suggest that developmental improvements in inhibitory control are primarily supported by changes in prefrontal executive function. However, studies are contradictory with respect to how activation in prefrontal regions changes with age, and they have yet to analyze longitudinal data using growth curve modeling, which allows characterization of dynamic processes of developmental change, individual differences in growth trajectories, and variables that predict any interindividual variability in trajectories. In this study, we present growth curves modeled from longitudinal fMRI data collected over 302 visits (across ages 9 to 26 years) from 123 human participants. Brain regions within circuits known to support motor response control, executive control, and error processing (i.e., aspects of inhibitory control) were investigated. Findings revealed distinct developmental trajectories for regions within each circuit and indicated that a hierarchical pattern of maturation of brain activation supports the gradual emergence of adult-like inhibitory control. Mean growth curves of activation in motor response control regions revealed no changes with age, although interindividual variability decreased with development, indicating equifinality with maturity. Activation in certain executive control regions decreased with age until adolescence, and variability was stable across development. Error-processing activation in the dorsal anterior cingulate cortex showed continued increases into adulthood and no significant interindividual variability across development, and was uniquely associated with task performance. These findings provide evidence that continued maturation of error-processing abilities supports the protracted development of inhibitory control over adolescence, while motor response control regions provide early-maturing foundational capacities and suggest that some executive control regions may buttress immature networks as error processing continues to mature.