MERSACIDIN, A NEW ANTIBIOTIC FROM BACILLUS INVITRO AND INVIVO ANTIBACTERIAL ACTIVITY
MERSACIDIN, A NEW ANTIBIOTIC FROM BACILLUS INVITRO AND INVIVO ANTIBACTERIAL ACTIVITY
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DOI：
10.7164/antibiotics.45.839
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发表时间：
1992-06-01
影响因子：
3.3
通讯作者：
SEIBERT, G
中科院分区：
文献类型：
--
作者：
CHATTERJEE, S;CHATTERJEE, DK;SEIBERT, G
Mersacidin是lantibiotic家族中的一种新的肽类抗生素。 它在体外和体内对革兰氏阳性菌（包括耐甲氧西林葡萄球菌）具有活性。 其体外活性低于万古霉素和红霉素，但在体内系统中显示出比体外试验结果预期的活性高得多的活性。 已经制备了一种水溶性钾盐，其具有与mersacidin相似的活性特征，但比母体化合物具有更好的抗化脓性链球菌的体内活性。
Mersacidin is a new peptide antibiotic of the proposed lantibiotic family. It is active in vitro and in vivo against Gram-positive bacteria including the methicillin-resistant Staphylococci. Its in vitro activity is less than those of vancomycin and erythromycin but it shows much higher activity in the in vivo system than can be expected from the in vitro testing results. A water soluble potassium salt has been prepared which has an activity profile similar to that of mersacidin, but has better in vivo activity against Streptococcus pyogenes than the parent compound.